Structure-activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents was written by Mizuhara, Tsukasa;Kato, Takayuki;Hirai, Atsushi;Kurihara, Hideki;Shimada, Yasuhiro;Taniguchi, Masahiko;Maeta, Hideki;Togami, Hiroaki;Shimura, Kazuya;Matsuoka, Masao;Okazaki, Shiho;Takeuchi, Tomoki;Ohno, Hiroaki;Oishi, Shinya;Fujii, Nobutaka. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.COA of Formula: C7H4ClNO4 This article mentions the following:
The structure-activity relationship of phenylpyrazole derivative 1 was investigated for the development of novel anti-HIV agents. Initial efforts revealed that the diazenyl group can be replaced by an aminomethylene group. In addition, we synthesized various derivatives by the reductive amination of benzaldehydes with 5-aminopyrazoles and carried out parallel structural optimization on the benzyl group and the pyrazole ring. This optimization led to a six-fold more potent derivative 32j than the lead compound 1, and this derivative has a 3′,4′-dichloro-(1,1′-biphenyl)-3-yl group. In the experiment, the researchers used many compounds, for example, 3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7COA of Formula: C7H4ClNO4).
3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.COA of Formula: C7H4ClNO4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics