Design and synthesis of prodrugs of the rat selective toxicant norbormide was written by Rennison, David;Laita, Olivia;Bova, Sergio;Cavalli, Maurizio;Hopkins, Brian;Linthicum, Darwin S.;Brimble, Margaret A.. And the article was included in Bioorganic & Medicinal Chemistry in 2012.Related Products of 5335-05-7 This article mentions the following:
Norbormide [5-(α-hydroxy-α-2-pyridylbenzyl)-7-(α-2-pyridylbenzylidene)-5-norbornene-2,3-dicarboximide] (NRB), an existing but infrequently used rodenticide, is known to be uniquely toxic to rats but relatively harmless to other rodents and mammals. However, one major drawback of NRB as a viable rodenticide relates to an evolutionary aversion developed by the rat leading to sub-lethal dosing due to either its unpleasant taste or rapid onset of effects. A series of NRB prodrugs were prepared in an effort to mask this acute response. Their synthesis and biol. evaluation (in vitro vasoconstrictory activity, in vitro hydrolytic and enzymic stability and lethality/palatability in vivo) is described. Compound 19 displayed the most promising profile with respect to a delay in the onset of symptoms and was subsequently demonstrated to be significantly more palatable to rats. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Related Products of 5335-05-7).
Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Related Products of 5335-05-7
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics