2-Phenylbenzimidazoles as potential anthelmintics was written by Sluka, J.;Novak, J.;Budesinsky, Z.. And the article was included in Collection of Czechoslovak Chemical Communications in 1976.Quality Control of 5-Chloro-2-methoxybenzoic acid This article mentions the following:
The reaction of o-C6H4(NH2)2 with various 5-chloro-, 3,5-dichloro-, 3,5,6-trichloro-, 5-bromo-, and 3,5-dibromo-substituted 2-ROC6H4CO2H (R = H, Me, Et, Pr, Me2CH, Bu, n-C5H11, n-C6H13, n-C12H25, MeOCH2CH2, PhCH2, o-, m-, and p-ClC6H4CH2, and 3,4-Cl2C6H3CH2) and with 2-RSC6H4CO2H (R = H, Me, Et, Pr, Me2CHCH2) gave the corresponding substituted 2-phenylbenzimidazole (I). Some of these derivatives showed a low anthelmintic activity on Nippostrongylus brasiliensis (9 compounds) and Hymenolepis nana (4 compounds) worms. A low coccidiostatic effect against Eimeria tenella was found only with I substituted at positions 2 and 5 of the Ph group by 2-ClC6H4CH2O and Cl, resp. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Quality Control of 5-Chloro-2-methoxybenzoic acid).
5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Quality Control of 5-Chloro-2-methoxybenzoic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics