Stefanowicz, Jacek et al. published their research in Medicinal Chemistry Research in 2018 | CAS: 620-19-9

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of 1-(Chloromethyl)-3-methylbenzene

Synthesis and biological investigations of 3β-aminotropane arylamide derivatives with atypical antipsychotic profile was written by Stefanowicz, Jacek;Slowinski, Tomasz;Wrobel, Martyna Z.;Slifirski, Grzegorz;Dawidowski, Maciej;Stefanowicz, Zdzislawa;Jastrzebska-Wiesek, Magdalena;Partyka, Anna;Wesolowska, Anna;Turlo, Jadwiga. And the article was included in Medicinal Chemistry Research in 2018.Quality Control of 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

This work is a continuation of our previous research, concentrating this time on lead structure modification to increase the 5-HT1A receptor affinity and water solubility of designed compounds Therefore, the compounds synthesized within the present project included structural analogs of 3β-acylamine derivatives of tropane with the introduction of a Me substituent in the benzyl ring and a 2-quinoline, 3-quinoline, or 6-quinoline moiety. A series of novel 3β-aminotropane derivatives was evaluated for their affinity for 5-HT1A, 5-HT2A, and D2 receptors, which allowed for the identification of compounds I, II, and III as ligands with highest affinity for the tested receptors; they were then subjected to further evaluation in preliminary in vivo studies. Selected compounds II and III displayed antipsychotic properties in the d-amphetamine-induced and MK-801-induced hyperlocomotor activity test in mice. Moreover, compound III showed significant antidepressant-like activity in the forced swim test in mice. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Quality Control of 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics