Design, synthesis and anticancer activity studies of novel trimethoxyphenyl-quinoline derivatives was written by Wu, Bowen;Cui, Xinxin;Zhu, Ting;Wang, Shenghui;Lu, Chaofan;Wang, Jinjie;Dang, Hexiang;Zhang, Saiyang;Ding, Li-na;Jin, Chengyun. And the article was included in Youji Huaxue in 2020.Recommanded Product: 620-19-9 This article mentions the following:
A series of novel trimethoxyphenyl-quinoline hybrids I [R = 4-MeC6H4, 4-FC6H4, 5-Cl-2-thienyl, etc.] were designed, synthesized and evaluated for antiproliferative activity against three human cancer cell lines. Compound I [R = 3-ClCH2C6H4] showed the most potent antitumor activity against PC-3 cells with IC50 value of 9.23μmol/L. Meanwhile, compound I [R = 3-ClCH2C6H4] inhibited the cell viability and colony formation of PC-3 cells. Further mechanism studies revealed that compound I [R = 3-ClCH2C6H4] could arrest PC-3 cells in G2/M phase and induce cell apoptosis via activating intrinsic and extrinsic apoptosis pathway. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Recommanded Product: 620-19-9).
1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 620-19-9
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics