Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT4R) partial agonist and 5-HT6R antagonist activities, as potential treatment of Alzheimer’s disease was written by Yahiaoui, Samir;Hamidouche, Katia;Ballandonne, Celine;Davis, Audrey;Santos, Jana Sopkova de Oliveira;Freret, Thomas;Boulouard, Michel;Rochais, Christophe;Dallemagne, Patrick. And the article was included in European Journal of Medicinal Chemistry in 2016.Recommanded Product: 2,4-Dimethoxybenzene-1-sulfonyl chloride This article mentions the following:
Seventeen novel derivatives of RS67333 (1) were synthesized and evaluated as potential dual-target compounds Among them, four agents showed nanomolar and submicromolar affinities toward 5-HT4R and 5-HT6R, resp.; one of them, 4-Amino-N-(2-(4-(3-(4-amino-5-chloro-2-methoxyphenyl)3-oxopropyl)piperidin-1-yl) ethyl)-3-bromobenzenesulfonamide, was selected on the basis of its in-vitro affinity (Ki5-HT4R = 5.3 nM, Ki5-HT6R = 219 nM) for further in-vivo experiments, where it also showed an antiamnesic effect in the mouse at 1 mg/kg i.p. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Recommanded Product: 2,4-Dimethoxybenzene-1-sulfonyl chloride).
2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 2,4-Dimethoxybenzene-1-sulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics