Easy one-pot synthesis of 1-monosubstituted aliphatic 1,2,3-triazoles from aliphatic halides, sodium azide and propiolic acid by a click cycloaddition/decarboxylation Process was written by Zhang, Zhongkui;Kuang, Chunxiang. And the article was included in Chinese Journal of Chemistry in 2013.Electric Literature of C7H5ClF2 This article mentions the following:
1-Monosubstituted aliphatic 1,2,3-triazoles were synthesized by a one-pot reaction from aliphatic halides (Cl and Br), sodium azide and propiolic acid. The yields ranged from moderate to good. The reaction was easily carried out in DMF with Cs2CO3 at 100° by copper-catalyzed click cycloaddition/decarboxylation. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Electric Literature of C7H5ClF2).
2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Electric Literature of C7H5ClF2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics