Month: December 2022

Synthesis and Characterization of Novel N-Propylaniline-Phenylpiperazine Sulfonamide and Urea Derivatives was written by Kazancioglu, Mustafa Zahrittin. And the article was included in Polycyclic Aromatic Compounds in 2022.Quality Control of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

Two different amino piperazine derivatives bearing various halogen groups were synthesized in high yields and explored in further transformations. Reacting these amino piperazines with various sulfonyl chlorides yielded eight different sulfonamides. Addnl., eight different urea derivatives have been prepared by treating these amino piperazines with isocyanates. Finally, we were able to take advantage of the aryl bromide functionality present in the parent amino piperazines by subjecting them to the Suzuki coupling with phenylboronic acid. Overall, we developed a strategy to diversify the amino piperazine core and obtained a small library of potentially bioactive piperazine derivatives In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Quality Control of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Quality Control of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Oxysterols Profile in Zebrafish Embryos Exposed to Triclocarban and Propylparaben-A Preliminary Study was written by Merola, Carmine;Vremere, Anton;Fanti, Federico;Iannetta, Annamaria;Caioni, Giulia;Sergi, Manuel;Compagnone, Dario;Lorenzetti, Stefano;Perugini, Monia;Amorena, Michele. And the article was included in International Journal of Environmental Research and Public Health in 2022.Recommanded Product: 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea This article mentions the following:

Oxysterols have long been considered as simple byproducts of cholesterol metabolism, but they are now fully designed as bioactive lipids that exert their multiple effects through their binding to several receptors, representing endogenous mediators potentially involved in several metabolic diseases. There is also a growing concern that metabolic disorders may be linked with exposure to endocrine-disrupting chems. (EDCs). To date, there are no studies aimed to link EDCs exposure to oxysterols perturbation-neither in vivo nor in vitro studies. The present research aimed to evaluate the differences in oxysterols levels following exposure to two metabolism disrupting chems. (propylparaben (PP) and triclocarban (TCC)) in the zebrafish model using liquid chromatog. coupled with tandem mass spectrometry (LC-MS/MS). Following exposure to PP and TCC, there were no significant changes in total and individual oxysterols compared with the control group; however, some interesting differences were noticed: 24-OH was detected only in treated zebrafish embryos, as well as the concentrations of 27-OH, which followed a different distribution, with an increase in TCC treated embryos and a reduction in zebrafish embryos exposed to PP at 24 h post-fertilization (hpf). The results of the present study prompt the hypothesis that EDCs can modulate the oxysterol profile in the zebrafish model and that these variations could be potentially involved in the toxicity mechanism of these emerging contaminants. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Recommanded Product: 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antibacterial activity of novel myricetin derivatives containing sulfonylpiperazine was written by He, Jun;Tang, Xue-Mei;Liu, Ting-Ting;Peng, Feng;Zhou, Qing;Liu, Li-Wei;He, Ming;Xue, Wei. And the article was included in Chemical Papers in 2021.Computed Properties of C7H4ClF3O2S This article mentions the following:

Myricetin derivatives containing sulfonylpiperazine were synthesized and their structures were confirmed by NMR and HRMS. The antibacterial activity results indicated that some compounds showed good antibacterial activity against Xanthomonas oryzaepv. oryzae (Xoo), Xanthomonas axonopodispv. citri (Xac) and Ralstonia solanacearum (Rs). Among them, compounds 4m and 4p revealed excellent antibacterial activities against Rs with a concentration for 50% of maximal effect (EC₅₀) value of 4 and 4 μg/mL, which were better than the control drugs bismerthiazol (13 μg/mL) and thiodiazole-copper (185 μg/mL). As observed using scanning electron microscope (SEM), these compounds act by causing folding and deformation of the bacterial surface, resulting in incomplete bacterial structure, so as to achieve the goal of bacteriostasis. The myricetin derivatives synthesized are expected to guide the research direction of new antibacterial agents. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Computed Properties of C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Computed Properties of C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Biodegradation and detoxification of aliphatic and aromatic hydrocarbons by new yeast strains was written by Hashem, Mohamed;Alamri, Saad A.;Al-Zomyh, Sharefah S. A. A.;Alrumman, Sulaiman A.. And the article was included in Ecotoxicology and Environmental Safety in 2018.Name: 1-Chlorooctadecane This article mentions the following:

Seeking new efficient hydrocarbon-degrading yeast stains was the main goal of this study. Because microorganisms are greatly affected by the environmental factors, the biodegradation potentiality of the microorganisms varies from climatic area to another. This induces research to develop and optimize the endemic organisms in bioremediation technol. In this study, 67 yeast strains were tested for their growth potentiality on both aliphatic and aromatic hydrocarbons. The most efficient six strains were identified using sequence anal. of the variable D1/D2 domain of the large subunit 26S ribosomal DNA. The identity of these strains was confirmed as Yamadazyma mexicana KKUY-0160, Rhodotorula taiwanensis KKUY-0162, Pichia kluyveri KKUY-0163, Rhodotorula ingeniosa KKUY-0170, Candida pseudointermedia KKUY-0192 and Meyerozyma guilliermondii KKUY-0214. These species are approved for their ability to degrade both aliphatic and aromatic hydrocarbons for the first time in this study. Although, all of them were able to utilize and grow on both hydrocarbons, Rhodotorula taiwanensis KKUY-0162 emerged as the best degrader of octane, and Rhodotorula ingeniosa KKUY-170 was the best degrader of pyrene. GC-MS anal. approved the presence of many chem. compounds that could be transitional or secondary metabolites during the utilization of the hydrocarbons. Our results recommend the application of these yeast species on large scale to approve their efficiency in bioremediation of oil-contamination of the environment. Using these yeasts, either individually or in consortia, could offer a practical solution for aquatic or soil contamination with the crude oil and its derivatives in situ. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Name: 1-Chlorooctadecane).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Name: 1-Chlorooctadecane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and Antimicrobial Activity of Some Novel [4-(1,2,3-thiadiazol-4-yl)phenoxy]methylene anchored 1,3,4-triazoles and 1,3,4-thiadiazoles was written by Gadhave, A. G.;Gaikar, R. B.;Kuchekar, S. R.;Karale, B. K.. And the article was included in Journal of Heterocyclic Chemistry in 2014.Recommanded Product: 6590-96-1 This article mentions the following:

A series of novel [4-(1,2,3-thiadiazol-4-yl)phenoxy]methylene-anchored 1,3,4-triazoles I (R = H, 2-F, 3-MeO, etc.) and 1,3,4-thiadiazoles II were synthesized from thiosemicarbazides III. The structures of these newly synthesized compounds were confirmed on the basis of IR, ¹H-NMR, mass spectral techniques, and elemental anal. The in vitro antimicrobial screenings of the synthesized compounds were carried out against four bacterial pathogens, namely Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa and three fungal pathogens Candida albicans, Aspergillus niger and Aspergillus clavatus, using broth microdilution min. inhibitory concentration method. The compounds I (R = H), II (R = H, 2-F), and III (R = 2-CF₃, 3-MeO) exhibited promising antibacterial activity against the tested strains, whereas some compounds were found to be active against one of the tested bacterial strains. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Recommanded Product: 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The synthesis of chiral 3-oxo-6-[(phenylmethoxy)carbonyl]-2-piperazineacetic acid esters designed for the presentation of an aspartic acid side chain. A subsequent novel Friedel Crafts reaction was written by Kogan, Timothy P.;Rawson, Thomas E.. And the article was included in Tetrahedron Letters in 1992.Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

The synthesis of the title esters (2S,6R)-I and (2S,6S)-I from L– or D-serine and dimethyl D-malate are described. Acylation of (2S,6S)-I with 3-methoxyphenylacetyl chloride, hydrogenolysis of the benzyl ester, followed by treatment with (COCl)₂ then AlCl₃ led to unexpected tricyclic product II into which a C₂O₂ unit had been incorporated. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

High-Throughput Catch-and-Release Synthesis of Oxazoline Hydroxamates. Structure-Activity Relationships in Novel Inhibitors of Escherichia coli LpxC: In Vitro Enzyme Inhibition and Antibacterial Properties was written by Pirrung, Michael C.;Tumey, L. Nathan;McClerren, Amanda L.;Raetz, Christian R. H.. And the article was included in Journal of the American Chemical Society in 2003.COA of Formula: C9H9ClO2 This article mentions the following:

LpxC is a zinc amidase that catalyzes the second step of lipid A biosynthesis in Gram-neg. bacteria. Oxazolines incorporating a hydroxamic acid, which is believed to coordinate to the single essential zinc ion, at the 4-position are known inhibitors of this enzyme. Some of these enzyme inhibitors exhibit antibacterial activity through their inhibition of LpxC. A method has been developed for the synthesis of oxazolines using resin capture and ring-forming release that eliminates traditional purification steps and can be used in high-throughput synthesis. Using this method, oxazoline hydroxamates with diverse 2-substituents were prepared in library form as candidate inhibitors for LpxC. Two conventional methods for oxazoline synthesis were also applied to generate more than 70 compounds The groups at the 2-position included a wide variety of substituted aromatic rings and a limited selection of alkyl groups. These compounds were screened against wild-type and LpxC inhibitor-sensitive strains of Escherichia coli, as well as wild-type Pseudomonas aeruginosa. Inhibition of the E. coli LpxC enzyme was also investigated. A broad correlation between enzyme inhibitory and antibacterial activity was observed, and novel compounds were discovered that exhibit antibacterial activity but fall outside earlier-known structural classes. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0COA of Formula: C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An efficient route to 3-chlorojuglones was written by Bloomer, James L.;Gazzillo, Joseph A.. And the article was included in Tetrahedron Letters in 1989.Name: 4-Chloro-2,5-dimethoxybenzaldehyde This article mentions the following:

4-Chloro-2,5-dimethoxybenzaldehyde was prepared and converted in only 3 steps to 5-acetoxy-7-carboethoxy-3-chloro-1,4-naphthaquinone (I). Diels-Alder reaction of I afforded the tetracyclic enol ether II in a regiospecific manner. In the experiment, the researchers used many compounds, for example, 4-Chloro-2,5-dimethoxybenzaldehyde (cas: 90064-48-5Name: 4-Chloro-2,5-dimethoxybenzaldehyde).

4-Chloro-2,5-dimethoxybenzaldehyde (cas: 90064-48-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Name: 4-Chloro-2,5-dimethoxybenzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of quinoxaline derivatives from benzofuroxan (Part II) was written by Kim, Ho Sik;Hur, Jae Hyuck. And the article was included in Journal of the Korean Chemical Society in 2005.HPLC of Formula: 6834-42-0 This article mentions the following:

Synthesis of 2-ethoxycarbonyl-3-methylquinoxaline 1,4-dioxide (I) from benzofuroxan and Et acetoacetate was accomplished. The reaction of compound I with hydrazine hydrate gave 2-hydrazinocarbonyl-3-methylquinoxaline 1,4-dioxide (II). The reactions of compound II with substituted phenylacetyl chlorides, benzyl chloroformate, heteroaryl aldehydes and acid anhydrides afforded 3-methyl-2-(substituted hydrazinocarbonyl)quinoxaline 4-oxides III [R = H, OMe], IV, V [X = O, S] and VI [R = Me, ethyl], resp. The reaction of compound II with isothiocyanates afforded 3-methyl-2-[(N-substituted thiocarbamoyl)hydrazinocarbonyl]quinoxaline 4-oxides VII [e.g., R = methyl], and followed reflux in 2N NaOH resulted in the intramol. cyclization to give 3-methyl-2-(4-substituted-3-thioxo-1,2,4-triazol-5-yl)quinoxaline 4-oxides VIII [e.g., R = methyl]. The herbicidal and fungicidal activities of the synthesized compounds were investigated. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0HPLC of Formula: 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and anticancer activity studies of novel trimethoxyphenyl-quinoline derivatives was written by Wu, Bowen;Cui, Xinxin;Zhu, Ting;Wang, Shenghui;Lu, Chaofan;Wang, Jinjie;Dang, Hexiang;Zhang, Saiyang;Ding, Li-na;Jin, Chengyun. And the article was included in Youji Huaxue in 2020.Recommanded Product: 620-19-9 This article mentions the following:

A series of novel trimethoxyphenyl-quinoline hybrids I [R = 4-MeC₆H₄, 4-FC₆H₄, 5-Cl-2-thienyl, etc.] were designed, synthesized and evaluated for antiproliferative activity against three human cancer cell lines. Compound I [R = 3-ClCH₂C₆H₄] showed the most potent antitumor activity against PC-3 cells with IC₅₀ value of 9.23μmol/L. Meanwhile, compound I [R = 3-ClCH₂C₆H₄] inhibited the cell viability and colony formation of PC-3 cells. Further mechanism studies revealed that compound I [R = 3-ClCH₂C₆H₄] could arrest PC-3 cells in G2/M phase and induce cell apoptosis via activating intrinsic and extrinsic apoptosis pathway. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Recommanded Product: 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics