Month: December 2022

Late-stage installation of dehydroamino acid motifs into peptides enabled by an N-chloropeptide strategy was written by Nanjo, Takeshi;Oshita, Takuma;Matsumoto, Ayaka;Takemoto, Yoshiji. And the article was included in Chemistry – A European Journal in 2022.Category: chlorides-buliding-blocks This article mentions the following:

Conventional methods for the construction of dehydroamino acids (ΔAAs), which are a unique class of non-proteinogenic amino acids, require the pre-installation of special amino acids. Herein, we report and demonstrate the practical utility of an N-chloropeptide strategy for the rapid construction of ΔAA-containing peptides. The electrophilic N-chlorination of peptide bonds is drastically accelerated by a catalytic amount of quinuclidine (ABCO), and the subsequent β-elimination of N-chloroamide efficiently provides ΔAA-containing peptides in high yield. The strategy enables, for the first time, the construction of a wide variety of ΔAA residues in peptides without any pre-functionalized side chains and facilitates the late-stage installation of ΔAA motifs into already-constructed oligopeptides, including a medicinally important macrocyclic peptide. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Category: chlorides-buliding-blocks).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An improved method of amide synthesis using acyl chlorides was written by Zhang, Li;Wang, Xiao-Jun;Wang, Jing;Grinberg, Nelu;Krishnamurthy, Dhileep Kumar;Senanayake, Chris H.. And the article was included in Tetrahedron Letters in 2009.Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

A simple, mild and highly efficient condition for amide synthesis from acyl chlorides has been developed to minimize hydrolysis, racemization and other side reactions. This method should expand capabilities in the peptide coupling area. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Long-lived states to sustain SABRE hyperpolarised magnetisation was written by Roy, Soumya S.;Rayner, Peter J.;Norcott, Philip;Green, Gary G. R.;Duckett, Simon B.. And the article was included in Physical Chemistry Chemical Physics in 2016.Related Products of 442903-28-8 This article mentions the following:

The applicability of the magnetic resonance (MR) technique in the liquid phase is limited by poor sensitivity and short nuclear spin coherence times which are insufficient for many potential applications. Here the authors illustrate how it is possible to address both of these issues simultaneously by harnessing long-lived hyperpolarized spin states that are formed by adapting the Signal Amplification by Reversible Exchange (SABRE) technique. The authors achieve >4% net ¹H-polarization in a long-lived form that remains detectable for over ninety seconds by reference to proton pairs in the biol. important mol. nicotinamide and a pyrazine derivative whose in vivo imaging will offer a new route to probe disease in the future. In the experiment, the researchers used many compounds, for example, Methyl 2,4-dichloronicotinate (cas: 442903-28-8Related Products of 442903-28-8).

Methyl 2,4-dichloronicotinate (cas: 442903-28-8) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Related Products of 442903-28-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The effect of C_X (alkyl groups) on the migration insertion polymerization (MIP) of ^PFpC_X [^PFp = (PPh₂(CH₂)₃Cp)Fe(CO)₂] was written by Lo, Ping Hsun;Wang, Xiaosong. And the article was included in Polymer in 2022.COA of Formula: C18H37Cl This article mentions the following:

Migration insertion polymerization (MIP) of organometallic monomers, ^PFpC_X [^PFp = (PPh₂(CH₂)₃Cp)Fe(CO)₂, C_X = (CH₂)_X-1CH₃, X = 12 or 18] was performed under various conditions. The oligomerization occurred in accompany with the monomer cyclization generating ^PFpC_X small rings at the early stage, which was followed by a complete cyclization of the oligomers generating P(^PFpC_X)_n macrocycles. ^PFpC_X small rings could be completely removed via precipitating the crude products in a poor solvent for the macrocycles. The solution and bulk MIP of ^PFpC_X (X = 12 or 18) had a similar cyclization rate but both were significantly accelerated at a higher MIP temperature (100°C). It is explained by the temperature-dependent tendency for the cyclization. The dependence of d.p. (DP) on the MIP conditions was discussed and the self-assembly of resultant P(^PFpC₁₂)_n was examined In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2COA of Formula: C18H37Cl).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C18H37Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Easy one-pot synthesis of 1-monosubstituted aliphatic 1,2,3-triazoles from aliphatic halides, sodium azide and propiolic acid by a click cycloaddition/decarboxylation Process was written by Zhang, Zhongkui;Kuang, Chunxiang. And the article was included in Chinese Journal of Chemistry in 2013.Electric Literature of C7H5ClF2 This article mentions the following:

1-Monosubstituted aliphatic 1,2,3-triazoles were synthesized by a one-pot reaction from aliphatic halides (Cl and Br), sodium azide and propiolic acid. The yields ranged from moderate to good. The reaction was easily carried out in DMF with Cs₂CO₃ at 100° by copper-catalyzed click cycloaddition/decarboxylation. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Electric Literature of C7H5ClF2).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Electric Literature of C7H5ClF2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Stereoselective α-Tertiary Alkylation of N-(Arylacetyl)oxazolidinones was written by Shim, Eunjae;Zakarian, Armen. And the article was included in Synlett in 2020.Recommanded Product: 6834-42-0 This article mentions the following:

A method was developed for the α-tertiary alkylation of zirconium enolates of N-(arylacetyl)oxazolidinones. This reaction installed directly an all-carbon quaternary center vicinal to a benzylic tertiary carbon in a highly diastereoselective manner. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Recommanded Product: 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Preparation of glycosyl thiourea derivatives from glycosyl azides using sulfamic acid and sodium iodide in one-pot was written by Gucchait, Arin;Jana, Manas;Jana, Kuladip;Misra, Anup Kumar. And the article was included in Carbohydrate Research in 2016.Product Details of 6590-96-1 This article mentions the following:

Novel one-pot reaction conditions have been developed for the preparation of glycosyl thiourea derivatives directly from glycosyl azides mediated by a combination of sulfamic acid and sodium iodide. The reaction conditions were clean, non-toxic and the products were isolated in good to excellent yield. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Product Details of 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Product Details of 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and evaluation of tetrahydroisoquinoline derivatives against Trypanosoma brucei rhodesiense was written by Cullen, Danica R.;Gallagher, Ashlee;Duncan, Caitlin L.;Pengon, Jutharat;Rattanajak, Roonglawan;Chaplin, Jason;Gunosewoyo, Hendra;Kamchonwongpaisan, Sumalee;Payne, Alan;Mocerino, Mauro. And the article was included in European Journal of Medicinal Chemistry in 2021.Formula: C19H15Cl This article mentions the following:

In this study the synthesis and antitrypanosomal activity of 80 compounds I [X = CH, N; R = H, (R)-HO, C₆H₅CH₂O, etc; R¹ = H, HO, C₆H₅CH₂O, etc; R² = H, HO, 2-cyclohexylethoxy, etc; R³ = H, Me, Et, etc; R⁴ = H, H₃C(H₂C)₁₀] based around a core tetrahydroisoquinoline scaffold were reported. A detailed structure activity relationship was revealed, and five derivatives (two of which have been previously reported) with inhibition of T. b. rhodesiense growth in the sub-micromolar range were identified. Four of these I [X = N, R = (R)-HO, R¹ = 4-(4-chlorophenyl)phenylmethoxy, R² = R⁴ = H, R³ = Me; X = N, R = R² = R⁴ = H, R¹ = 4-phenylphenyl, R³ = Me; X = N, R = R¹ = HO, R² = (4-phenylphenyl)methoxy, R³ = R⁴ = H; X = N, R = (R)-HO, R¹ = HO, R² = H, R³ = Me, R⁴ = H₃C(H₂C)₁₀] were also found to have good selectivity over mammalian cells (SI > 50). Calculated logD values and preliminary ADME studies predict that these compounds I are likely to have good absorption and metabolic stability, with the ability to passively permeate the blood brain barrier. This makes them excellent leads for a blood-brain barrier permeable antitrypanosomal scaffold. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Formula: C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Formula: C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shape-controlled SnO and their improved properties in the field of gas sensor, photocatalysis, and lithium-ion battery was written by Ren, Qianqian;Zhang, Xinping;Guo, Yuxi;Xu, Manzhang;Zhu, Hongyang;Yun, Jiangni;Zhao, Wu;Zhang, Zhiyong;Wang, Yingnan. And the article was included in Sensors and Actuators, B: Chemical in 2022.Safety of 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride This article mentions the following:

In this paper, over 20 kinds of tin monoxide (SnO) morphologies are prepared by using a facile solvothermal process. Among all these obtained SnO materials, the shapes with unique morphologies such as bowl-, pompon-, sheet-, hollow frame-like structures exhibit excellent NO₂ gas sensing, photocatalytic degradation, and lithium-ion batteries properties due to their large sp. surface area and more active sites compared with other shapes. For the NO₂ gas sensors properties, these SnO with unique morphologies exhibit excellent sensing performance, including low detection limits (≤ 100 ppb, even reaching 5 ppb), short response and recovery time (< 100 s). Finally, the as-prepared SnO are used as the efficient photocatalysts and lithium-ion battery anode material. These performances have been improved significantly compared with other shaped SnO proposed by other reports. All these advantages indicate the huge application potential of SnO in the field of photocatalysis, gas sensitivity, and lithium-ion battery performance. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Safety of 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and Synthesis of the First Generation of Dithiolane Thiazolidinedione- and Phenylacetic Acid-Based PPARγ Agonists was written by Chittiboyina, Amar G.;Venkatraman, Meenakshi S.;Mizuno, Cassia S.;Desai, Prashant V.;Patny, Akshay;Benson, Stephen C.;Ho, Christopher I.;Kurtz, Theodore W.;Pershadsingh, Harrihar A.;Avery, Mitchell A.. And the article was included in Journal of Medicinal Chemistry in 2006.Application of 57017-95-5 This article mentions the following:

A series of novel derivatives of potent antioxidant vitamin, α-lipoic acid, and related analogs were designed, synthesized, and evaluated for their PPARγ agonist activities. Compounds I and the water soluble analog II (R = COCH₂NH₂.HCl) were found to be potent PPARγ agonists. I appeared to have a significant role in improving insulin sensitivity and reducing triglyceride levels in fa/fa rats as well as inhibited proliferation of a variety of normal and neoplastic cultured human cell types. These novel compounds may prove efficacious not only in the treatment of Type 2 diabetes, but also atherosclerosis, prevention of vascular restenosis, and inflammatory skin diseases. In the experiment, the researchers used many compounds, for example, Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5Application of 57017-95-5).

Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 57017-95-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics