Month: December 2022

Bis(pyridylimino)isoindolato-iridium complexes as epoxidation catalysts for alkenes was written by Camerano, Jose A.;Saemann, Christoph;Wadepohl, Hubert;Gade, Lutz H.. And the article was included in Organometallics in 2011.Recommanded Product: 39722-81-1 This article mentions the following:

The reaction of the Na salts of 1,3-bis(2-(5-(3,5-xylyl)pyridyl)imino)-5,6-dimethylisoindole (1a) and 1,3-bis(2-(4-tert-butylpyridyl)imino)-5,6-dimethylisoindole (1b) with [Ir(μ-Cl)(COD)]₂ (COD = cyclooctadiene) and [Ir(μ-Cl)(C₂H₄)₂]₂ afforded the corresponding isoindolato metallacyclic complexes I and II (R¹ = 3,5-xylyl, R² = H; R¹ = H, R² = tBu) resp. The catalytic activity of the complexes I was tested in the epoxidation of a wide range of nonelectron-rich olefins, using PPO (PPO = 3-phenyl-2-(phenylsulfonyl)-1,2-oxaziridine) as oxidizing agent, giving the corresponding epoxides in moderate to high yields. In the experiment, the researchers used many compounds, for example, Chlorobis(ethylene)iridium(I) dimer (cas: 39722-81-1Recommanded Product: 39722-81-1).

Chlorobis(ethylene)iridium(I) dimer (cas: 39722-81-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 39722-81-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

2H-Pyrrolo[3,4-b] [1,5]benzothiazepine derivatives as potential inhibitors of HIV-1 reverse transcriptase was written by Di Santo, Roberto;Costi, Roberta. And the article was included in Farmaco in 2005.Computed Properties of C7H5ClF2 This article mentions the following:

A number of 2H-pyrrolo[3,4-b] [1,5]benzothiazepine derivatives (PBTAs) 7-25 and the related synthetic intermediates 3-pyrrolyl aryl sulfones (PASs) 26-32 were designed, synthesized and tested as potential anti-HIV-1 agents targeted at the reverse transcriptase (RT). The PBTAs were conceived as tricyclic analogs of nevirapine, pyrrolo[1,2-b] [1,2,5]benzothiadiazepine 5 (PBTD) and pyrrolo[2,1-d] [1,2,5]benzothiadiazepine 6, NNRTIs endowed with potent anti-HIV-1 activities. The majority of tested PBTAs were active against HIV-1-induced cytopathicity in MT-4 cells at concentrations ranging from 0.3 to 40 μM. In particular, compound 10 was the most potent derivative with EC₅₀ = 0.3 μM, comparable to that of nevirapine used as reference drug. In the 3-pyrrolyl aryl sulfones (26-32) series only three sulfones were found active against HIV-1 replication cycle. The following preliminary SAR could be depicted for the title derivatives:(i) the conformationally restrained PBTAs are more potent than the corresponding open counterparts (PASs); (ii) the DMA group give the highest anti-HIV-1 potency in the PBTAs series; (iii) PBTAs and the corresponding thiones are equipotent; (iv) an unsubstituted amino group, as part of p-chloroanilino moiety, is a strong determinant for the antiviral activity in the PASs series. The most potent derivatives in cell-based assays were proven to target the RT in enzyme assays. Unfortunately, none of the test compounds inhibited the multiplication of clin. relevant drug-resistant viruses (mutants of HIV-1 carrying K103N and Y181C mutations) at concentrations lower than 30 μM. However, the good results obtained against replication of wt HIV-1, lead us to consider compound 10 as a lead compound for further investigation in this field. In particular, our efforts will be directed to modifications of 10 devoted to obtain new derivatives active against HIV-1 mutant strains. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Computed Properties of C7H5ClF2).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Computed Properties of C7H5ClF2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent was written by Zhu, Weixing;Haupenthal, Joerg;Groh, Matthias;Fountain, Michelle;Hartmann, Rolf W.. And the article was included in Antimicrobial Agents and Chemotherapy in 2014.Related Products of 1711-11-1 This article mentions the following:

CBR703 was reported to inhibit bacterial RNA polymerase (RNAP) and biofilm formation, considering it to be a good candidate for further optimization. While synthesized derivatives of CBR703 did not result in more-active RNAP inhibitors, we observed promising antibacterial activities. These again correlated with a significant cytotoxicity toward mammalian cells. Furthermore, we suspect the promising effects on biofilm formation to be artifacts. Consequently, this class of compounds can be considered unattractive as antibacterial agents. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Related Products of 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Related Products of 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Intramolecular Addition of a Dimethylamino C(sp³)-H Bond across C-C Triple Bonds Using IrCl(DTBM-SEGPHOS)(ethylene) Catalyst: Synthesis of Indoles from 2-Alkynyl-N-methylanilines was written by Ohmura, Toshimichi;Yagi, Kaito;Torigoe, Takeru;Suginome, Michinori. And the article was included in Synthesis in 2021.Reference of 39722-81-1 This article mentions the following:

Intramol. addition of a C(sp³)-H bond of the dimethylamino group across the C-C triple bond in 2-alkynyl-N,N-dimethylanilines is effectively catalyzed by a new iridium complex, IrCl(DTBM-SEGPHOS)(C ₂H₄), in mesitylene at 150°C. The intramol. C(sp³)-H addition is followed by double-bond isomerization to afford 3-substituted indoles in good to high yields. In the experiment, the researchers used many compounds, for example, Chlorobis(ethylene)iridium(I) dimer (cas: 39722-81-1Reference of 39722-81-1).

Chlorobis(ethylene)iridium(I) dimer (cas: 39722-81-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Reference of 39722-81-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Assessing the impact of membrane support and different amine monomer structures on the efficacy of thin-film composite nanofiltration membrane for dye/salt separation was written by Wu, Ping-Han;Gallardo, Marwin R.;Ang, Micah Belle Marie Yap;Millare, Jeremiah C.;Huang, Shu-Hsien;Tsai, Hui-An;Lee, Kueir-Rarn. And the article was included in Journal of Polymer Research in 2022.Formula: C9H3Cl3O3 This article mentions the following:

The right choice of porous support and diamine monomer is crucial in fabricating TFC membranes with improved performance. In this study, the effect of the supporting layer and diamine monomer structure in preparing TFC membranes for dye/salt separation was investigated. Supports used are polysulfone (PSf), polyacrylonitrile (PAN), and hydrolyzed PAN (mPAN) while diamine monomers used are piperazine (PIP), 1,3-diaminopropane (DAPE), and 1,4-bis(3-aminopropyl) piperazine (BAPP). Changing the porous substrate and monomer not only affects membrane phys. and chem. morphol. but also the performance of TFC NF membranes. Characterization and NF tests revealed that the TFC membrane prepared using mPAN as support and PIP as diamine monomer had most hydrophilic, roughest surface, and lowest crosslinking degree, and it delivered the optimum NF performance: J = 127.66 ± 12.61 LMH; R_{Brilliant Blue} = 99.28 ± 0.57% R_Congo Red = 99.21 ± 0.08%; R_NaCl = 14.00 ± 6.16%. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Formula: C9H3Cl3O3).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Formula: C9H3Cl3O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Metal-free C-N cross-coupling of electrophilic compounds and N-haloimides was written by Zhang, Luyan;Li, Yanru;Jin, Long-Yi;Liang, Fushun. And the article was included in RSC Advances in 2015.Electric Literature of C7H4ClNO3S This article mentions the following:

The methodol. represents an elegant example of applying the halogen bond activation strategy in an organic transformation. When DBU is added, the cross-coupling reaction between alkyl halides, RX (R = Bn, Et, 2-oxocyclopentyl, etc.; X = Cl, Br, I) and N-haloimides, e.g., I occurs, resulting in the formation of aminated products e.g., II. A halogen bond activated nucleophilic substitution mechanism was proposed. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Electric Literature of C7H4ClNO3S).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Electric Literature of C7H4ClNO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Emerging organic contaminants and odorous compounds in secondary effluent wastewater: Identification and advanced treatment was written by Chen, Li;Fu, Wanyi;Tan, Yu;Zhang, Xihui. And the article was included in Journal of Hazardous Materials in 2021.Synthetic Route of C13H9Cl3N2O This article mentions the following:

This study aims to address organic micropollutants in secondary effluents from municipal wastewater treatment plants (WWTPs) by first identification of micropollutants in different treatment units, and second by evaluating an advanced treatment process for removals of micropollutants. In secondary effluents, 28 types of pharmaceutical and personal care products (PPCPs), 5 types of endocrine disrupting chems. (EDCs) and 3 types of odorous compounds are detected with total concentrations of 513 ± 57.8 ng/L, 991 ± 36.5 ng/L, 553 ± 48.3 ng/L, resp. An integrated process consisting of in-situ ozonation, ceramic membrane filtration (CMF) and biol. active carbon (BAC) filtration is investigated in a pilot scale (1000 m³/d) for removal of micropollutants in secondary effluents. The total removal efficiencies of PPCPs, EDCs and odorous compounds are 98.5%, 95.4%, and 91.1%, resp. Removal mechanisms of emerging organic contaminants (EOCs) and odorous compounds are discussed based on their physicochem. properties. The remarkable removal efficiencies of micropollutants by the pilot system is attributed to synergistic effects of combining ozonation, ceramic membrane filtration and BAC filtration. This study provides a cost-effective and robust technol. with the capability of treating secondary effluents for reuse applications. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Synthetic Route of C13H9Cl3N2O).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Synthetic Route of C13H9Cl3N2O

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

2-Phenylbenzimidazoles as potential anthelmintics was written by Sluka, J.;Novak, J.;Budesinsky, Z.. And the article was included in Collection of Czechoslovak Chemical Communications in 1976.Quality Control of 5-Chloro-2-methoxybenzoic acid This article mentions the following:

The reaction of o-C6H4(NH2)2 with various 5-chloro-, 3,5-dichloro-, 3,5,6-trichloro-, 5-bromo-, and 3,5-dibromo-substituted 2-ROC6H4CO2H (R = H, Me, Et, Pr, Me2CH, Bu, n-C5H11, n-C6H13, n-C12H25, MeOCH2CH2, PhCH2, o-, m-, and p-ClC6H4CH2, and 3,4-Cl2C6H3CH2) and with 2-RSC6H4CO2H (R = H, Me, Et, Pr, Me2CHCH2) gave the corresponding substituted 2-phenylbenzimidazole (I). Some of these derivatives showed a low anthelmintic activity on Nippostrongylus brasiliensis (9 compounds) and Hymenolepis nana (4 compounds) worms. A low coccidiostatic effect against Eimeria tenella was found only with I substituted at positions 2 and 5 of the Ph group by 2-ClC6H4CH2O and Cl, resp. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Quality Control of 5-Chloro-2-methoxybenzoic acid).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Quality Control of 5-Chloro-2-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and solution behaviour of metal-carbonyl amphiphiles with an Fp (CpFe(CO)₂) junction was written by Murshid, Nimer;El-Temtamy, Abdelrahman;Wang, Xiaosong. And the article was included in Journal of Organometallic Chemistry in 2017.Safety of 1-Chlorooctadecane This article mentions the following:

Metallo-amphiphilic macromols. with an iron-carbonyl junction (PEGPPh₂-FpR, PEGPPh₂: polyethylene glycol di-Ph phosphine, M_n, PEG = 550 or 2000 g/mol; R = octadecyl or hexyl; Fp = CpFe(CO)₂) are synthesized via migration insertion reaction of FpR in the presence of PEGPPh₂ and are characterized using ³¹P, ¹H NMR and IR. The prepared amphiphiles are air stable, soluble in most organic solvents, e.g.THF, DCM, DMF, and exhibit a reversible redox activity as indicated by cyclic voltammetry (CV) experiments Surface tension measurements indicate that the prepared mols. exhibit typical amphiphilic properties with critical micelle concentrations (CMC) in water ranging between 30 and 113 μM. The aqueous micelles aggregated from PEGPPh₂-FpR agglomerate into suspensions, which is similar with the solution behavior of Brij surfactants, the organic analog without the Fp junction. The redox activity of Fp junction in 1-4, which is sensitive to assembling structures, will be a possible advantage for further investigation on this agglomeration behavior. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Safety of 1-Chlorooctadecane).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of 1-Chlorooctadecane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents was written by Mizuhara, Tsukasa;Kato, Takayuki;Hirai, Atsushi;Kurihara, Hideki;Shimada, Yasuhiro;Taniguchi, Masahiko;Maeta, Hideki;Togami, Hiroaki;Shimura, Kazuya;Matsuoka, Masao;Okazaki, Shiho;Takeuchi, Tomoki;Ohno, Hiroaki;Oishi, Shinya;Fujii, Nobutaka. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.COA of Formula: C7H4ClNO4 This article mentions the following:

The structure-activity relationship of phenylpyrazole derivative 1 was investigated for the development of novel anti-HIV agents. Initial efforts revealed that the diazenyl group can be replaced by an aminomethylene group. In addition, we synthesized various derivatives by the reductive amination of benzaldehydes with 5-aminopyrazoles and carried out parallel structural optimization on the benzyl group and the pyrazole ring. This optimization led to a six-fold more potent derivative 32j than the lead compound 1, and this derivative has a 3′,4′-dichloro-(1,1′-biphenyl)-3-yl group. In the experiment, the researchers used many compounds, for example, 3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7COA of Formula: C7H4ClNO4).

3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.COA of Formula: C7H4ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics