Month: December 2022

β-Sulfonamido Functionalized Aspartate Analogues as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype Selectivity Profiles Arising from Subtle Structural Differences was written by Hansen, Jacob C.;Bjoern-Yoshimoto, Walden E.;Bisballe, Niels;Nielsen, Birgitte;Jensen, Anders A.;Bunch, Lennart. And the article was included in Journal of Medicinal Chemistry in 2016.SDS of cas: 777-44-6 This article mentions the following:

In this study inspired by previous work on 3-substituted Asp analogs, the authors designed and synthesized a total of 32 beta-sulfonamide Asp analogs and characterized their pharmacol. properties at the excitatory amino acid transporter subtypes EAAT1, EAAT2 and EAAT3. In addition to several potent EAAT inhibitors displaying IC₅₀ values ∼1 μM at all three subtypes, this elaborate structure-activity-relationship also identified analogs characterized by distinct preference or selectivity for one transporter subtype. Introduction of two fluorine atoms on the Ph ring yielded the analog that displayed an IC₅₀ of 0.8 μM at EAAT1 with a 14- and 9-fold preference over EAAT2 and EAAT3, resp. Conversely, the m-CF₃-Ph analog was a potent selective EAAT2-inhibitor (IC₅₀= 2.8 μM) exhibiting 30- and 50-fold selectivity over EAAT1 and EAAT3, resp. In conclusion, even small structural differences in these beta-sulfonamide Asp analogs provide analogs with diverse EAAT subtype selectivity profiles. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6SDS of cas: 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.SDS of cas: 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Visible-light-promoted aerobic oxidation of sulfides and sulfoxides in ketone solvents was written by Li, Xiaotong;Wang, Yu;Yang, Liqun;Zhang, Zhaoguo;Xie, Xiaomin. And the article was included in Tetrahedron in 2022.SDS of cas: 85953-29-3 This article mentions the following:

Simple and readily available ketones have been identified to promote the visible-light-promoted aerobic oxidation of sulfides and sulfoxides to sulfones. A simple and environmental-friendly oxidation protocol of sulfides to sulfones is reported. Various sulfides were efficiently oxidized into sulfones with O₂ as sustainable terminate oxidant, readily available thioxanthone as the photocatalyst and 3-pentanone (DEK) as the solvent. The protocol tolerates diverse functional groups, including halogens, ketone, ester, cyano, heterocycle and even cyclopropyl groups. The detection of the aerobic oxidation reaction in DEK by GC and HRMS disclosed that the key active intermediates were generated. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3SDS of cas: 85953-29-3).

Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.SDS of cas: 85953-29-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Continuous-flow processing of gaseous ammonia using a teflon AF-2400 tube-in-tube reactor: synthesis of thioureas and in-line titrations was written by Browne, Duncan L.;O’Brien, Matthew;Koos, Peter;Cranwell, Philippa B.;Polyzos, Anastasios;Ley, Steven V.. And the article was included in Synlett in 2012.COA of Formula: C7H3Cl2NS This article mentions the following:

A simple tube-in-tube reactor based on the gas-permeable membrane Teflon AF-2400 was used in the continuous flow reaction of gaseous ammonia with isothiocyanates and one isocyanate. A colorimetric in-line titration technique is also reported as a simple method to quantify the amount of ammonia taken up by the solvent in the system. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1COA of Formula: C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.COA of Formula: C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Role of pKa in establishing crystal structures of six hydrogen-bonded compounds of with different isomers of chloro- and nitro-substituted benzoic acids was written by Ishida, Hiroyuki. And the article was included in Acta Crystallographica, Section E: Crystallographic Communications in 2021.Category: chlorides-buliding-blocks This article mentions the following:

The structures of the six hydrogen-bonded 1:1 compounds of 4-methylquinoline (C₁₀H₉N) with chloro- and nitro-substituted benzoic acids (C₇H₄ClNO₄), namely, 4-methylquinolinium 2-chloro-4-nitrobenzoate, C₁₀H₁₀N⁺·C₇H₃ClNO^4-, (I), 4-methylquinoline-2-chloro-5-nitrobenzoic acid (1/1), C₁₀H₉N·C₇H₄ClNO₄, and (II), 4-methylquinolinium 2-chloro-6-nitrobenzoate, C₁₀H_9.63N_0.63⁺·C₇H_3.37ClNO₄^0.63-. The (III), 4-methylquinolinium 3-chloro-2-nitrobenzoate, C₁₀H_9.54N^0.54+·C₇H_3.46ClNO₄^0.54-, (IV), 4-methylquinolinium 4-chloro-2-nitrobenzoate, C₁₀H₁₀N⁺·C₇H₃ClNO^4-, (V), and 4-methylquinolinium 5-chloro-2-nitrobenzoate, C₁₀H₁₀N⁺·C₇H₃ClNO^4-, have been determined at 185-190 K. In each compound, the acid and base mols. are linked by a short hydrogen bond between a carboxy (or carboxylate) O atom and an N atom of the base. The O···N distances are 2.5652 (14), 2.556 (3), 2.5485 (13), 2.5364 (13), 2.5568 (13) and 2.5252 (11) Å, resp., for compounds (I)-(VI). In the hydrogen-bonded acid-base units of (III) and (IV), the H atoms are each disordered over two positions with O site:N site occupancies of 0.37 (3):0.63 (3) and 0.46 (3):0.54 (4), resp., for (III) and (IV). The H atoms in the hydrogen-bonded units of (I), (V) and (VI) are located at the N-atom site, while the H atom in (II) is located at the O-atom site. In all the crystals of (I)-(VI), π-π stacking interactions between the quinoline ring systems and C-H···O hydrogen bonds are observed Similar layer structures are constructed in (IV)-(VI) through these interactions together with π-π interactions between the benzene rings of the adjacent acid mols. A short Cl···Cl contact and an N-O···π interaction are present in (I), while a C-H···Cl hydrogen bond and a π-π interaction between the benzene ring of the acid mol. and the quinoline ring system in (II), and a C-H···π interaction in (III) are observed Hirshfeld surfaces for the title compounds mapped over dnorm and shape index were generated to visualize the weak intermol. interactions. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Category: chlorides-buliding-blocks).

2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic routes to 1,5-diazacyclooctanes via 2,6-dioxo-1,5-diazabicyclo[3.3.1]octanes was written by Kemp, D. S.;Sidell, M. D.;Shortridge, T. J.. And the article was included in Journal of Organic Chemistry in 1979.Recommanded Product: 5335-05-7 This article mentions the following:

Reactions of 3-pyrazolidinones with primary β-chloropropionyl chlorides provide a satisfactory synthetic route to 2,6-dioxo-1,5-diazabicyclo[3.3.0]octanes I (R = H, Me). The corresponding secondary halides cannot be induced to undergo cyclization. The Stetter procedure, reaction of acrylic acid derivatives with hydrazine at 200°, provides an acceptable route to derivatives that bear 4- or 8-alkyl substituents. Reactions of I with NaNH₂ in NH₃ generate sodium enolates that undergo C-alkylation and C-acylation reactions in high yield. Two new procedures are described for reduction of I to 1,5-diazacyclooctanes, treatment with diborane in refluxing THF and Na-NH₃ treatment, followed by reduction by LiAlH₄. Reductions of I with Na-NH₃ or by sodium naphthalenide in dimethoxyethane generate 2,6-dioxo-1,5-diazacyclooctanes in excellent yield. Convenient preparations of 3,6-dibromohexanoic acid and 2-acetyl-3-chloro-2-methylpropionic acid are described. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Recommanded Product: 5335-05-7).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 5335-05-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Optimal 10-aminoartemisinins with potent transmission-blocking capabilities for new artemisinin combination therapies-activities against blood stage P. falciparum Including PfKI3 C580Y mutants and liver stage P. berghei parasites was written by Wong, Ho Ning;Padin-Irizarry, Vivian;van der Watt, Mariette E.;Reader, Janette;Liebenberg, Wilna;Wiesner, Lubbe;Smith, Peter;Eribez, Korina;Winzeler, Elizabeth A.;Kyle, Dennis E.;Birkholtz, Lyn-Marie;Coertzen, Dina;Haynes, Richard K.. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2019.SDS of cas: 777-44-6 This article mentions the following:

We have demonstrated previously that amino-artemisinins including artemiside and artemisone in which an amino group replaces the oxygen-bearing substituents attached to C-10 of the current clin. artemisinin derivatives dihydroartemisinin (DHA), artemether and artesunate, display potent activities in vitro against the asexual blood stages of Plasmodium falciparum (Pf). In particular, the compounds are active against late blood stage Pf gametocytes, and are strongly synergistic in combination with the redox active drug methylene blue. In order to fortify the eventual selection of optimum amino-artemisinins for development into new triple combination therapies also active against artemisinin-resistant Pf mutants, we have prepared new amino-artemisinins based on the easily accessible and inexpensive DHA-piperazine. The latter was converted into alkyl- and aryl sulfonamides, ureas and amides. These derivatives were screened together with the comparator drugs DHA and the hitherto most active amino-artemisinins artemiside and artemisone against asexual and sexual blood stages of Pf and liver stage P. berghei (Pb) sporozoites. Several of the new amino-artemisinins bearing aryl-urea and -amide groups are potently active against both asexual, and late blood stage gametocytes (IC₅₀ 0.4-1.0 nM). Although the activities are superior to those of artemiside (IC₅₀ 1.5 nM) and artemisone (IC₅₀ 42.4 nM), the latter are more active against the liver stage Pb sporozoites (IC₅₀ artemisone 28 nM). In addition, early results indicate these compounds tend not to display reduced susceptibility against parasites bearing the Pf Kelch 13 propeller domain C580Y mutation characteristic of artemisinin-resistant Pf. Thus, the advent of the amino-artemisinins including artemiside and artemisone will enable the development of new combination therapies that by virtue of the amino-artemisinin component itself will possess intrinsic transmission-blocking capabilities and may be effective against artemisinin resistant falciparum malaria. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6SDS of cas: 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.SDS of cas: 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Facile preparation of pliable superamphiphobic papers with high and durable liquid repellency for anti-corrosion and open surface microfluidics was written by Jiao, Long;Xu, Qian;Tong, Jiangyi;Liu, Shuai;Hu, Yanjun;Guo, Qianqian;Wu, Huaping;Li, Wei;Zhao, Qinxin;Chen, Rong. And the article was included in Applied Surface Science in 2022.Recommanded Product: 61-73-4 This article mentions the following:

Flexible superamphiphobic surfaces show significant potential in anti-fouling, flexible electronics, droplet-based microfluidics, etc. However, there is a bottleneck in quickly generating pliable superamphiphobic surfaces with high liquid repellency and practicability. Here, a new method was proposed to create a superamphiphobic surface with high and durable liquid repellency by effortlessly one-step spraying the fluorinated TiO₂ nanoparticles onto the polymer paper. Even 90 vol% ethanol solution could keep the Cassie state on the surface. The adhesion strengthening of the nanoparticles agglomerates on the paper’s wires generated excellent robustness for resisting underwater ultrasonic shock, resulting in a failure time 2000-times longer than the smooth substrate. No significant degeneration of the paper was observed after storing for 90 days, bending for 1000 cycles, or heating at 200°C. Because of the attractive figurability, the paper could quickly fit on curved surfaces or internal walls. As a proof of concept, the superamphiphobic paper was successfully used for deformable anti-corrosion shelter and droplet-based anal. platform. This work opens a new avenue for accomplishing the long-sort task of efficiently fabricating flexible superamphiphobic surfaces with high comprehensive performances. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Recommanded Product: 61-73-4).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 61-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Detection of stx2 from Shiga toxin-producing Escherichia coli (STEC) by a surface enhanced Raman spectroscopy (SERS) sensor using recycled silicon chips was written by Yang, Yuqing;Wasiewska, Luiza Adela;Burgess, Catherine M.;Duffy, Geraldine;Lovera, Pierre;O’Riordan, Alan. And the article was included in Sensors and Actuators, B: Chemical in 2022.Safety of 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride This article mentions the following:

In this research, a selective, cost-efficient, and highly sensitive Ag nanostructure Surface Enhanced Raman Spectroscopy sensor was developed as a methodol. approach to rapidly detect a targetss-DNA (stx2) in STEC (Shiga toxin-producing Escherichia coli). The Ag nanostructure-based SERS substrate was functionalized by two types of thiols: thiol-ss-DNA for bonding target ss-DNA and 6-Mercapto-1-hexanol for blocking the Ag nanostructure surface. Methylene Blue (MB) was used as a Raman marker to quantify target ss-DNA, as well as a model mol. to characterize the electrodeposited Ag nanostructure SERS substrate. Ag nanostructure SERS substrates showed good sensitivity and repeatability towards MB detection, with a LOD = 0.3158μM, and RSD = 12.48% (at 45 different random points for 0.1μM MB). More importantly, the Ag nanostructure/ss-DNA SERS substrate showed good selectivity towards STEC O157 stx2 target DNA, as well as good linearity and sensitivity towards its detection in a buffer solution The SERS sensors were able to identify target DNA (stx2) in a STEC strain and the study showed proof of principle that SERS substrate has potential as a cost-effective, highly selective, highly sensitive DNA and bacteria sensor without the aid of DNA amplification. With further development and validation, this methodol. approach has the potential for point-of-use detection for instance on a farm or in the food industry. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Safety of 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Safety of 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Construction of axial chirality via asymmetric radical trapping by cobalt under visible light was written by Jiang, Xuan;Xiong, Wei;Deng, Shuang;Lu, Fu-Dong;Jia, Yue;Yang, Qian;Xue, Li-Yuan;Qi, Xiaotian;Tunge, Jon A.;Lu, Liang-Qiu;Xiao, Wen-Jing. And the article was included in Nature Catalysis in 2022.Related Products of 620-19-9 This article mentions the following:

The 3d metals have been identified as economic and sustainable alternatives to palladium, the frequently used metal in transition-metal-catalyzed cross-couplings. However, cobalt has long stood behind its neighboring elements, nickel and copper,in asym. radical couplings owing to its high catalytic activity in the absence of ligands resulting in unfavorable un-asym. background reactions. Here, the authors disclose an asym. metallaphotoredox catalysis (AMPC) strategy for the dynamic kinetic asym. transformation of racemic heterobiaryls, which represents a visible-light-induced, asym. radical coupling for the construction of axial chirality. This success can also extended to the reductive cross-coupling variant featuring the use of more easily available organic halide feedstocks. The keys to these achievements are the rational design of a sustainable AMPC system that merges asym. cobalt catalysis with organic photoredox catalysis in combination with the identification of an efficient chiral polydentate ligand. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Related Products of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Related Products of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Absolute configuration of endo-dicyclopentadiene. Crystal and molecular structure of (+)-(endo-dicyclopentadiene)platinum dichloride was written by Avitabile, G.;Ganis, P.;Lepore, U.;Panunzi, A.. And the article was included in Inorganica Chimica Acta in 1973.Recommanded Product: Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) This article mentions the following:

The absolute configuration of the dissym. olefin endo-dicyclopentadiene was determined This was achieved through the determination of the crystal and mol. structure of (+) (endo-dicyclopentadiene)platinum dichloride, which crystallizes in orthorhombic space group P212121 with cell parameters a 12.65 ± 0.05, b 12.40 ± 0.05, c 13.07 ± 0.05 Å, with d. (observed) = 2.56 and d. (x-ray) = 2.58 for Z = 8. In the experiment, the researchers used many compounds, for example, Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0Recommanded Product: Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II)).

Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II)

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics