Month: January 2023

Synthesis and characterization of novel fluorinated thiazolyl 1,3,4-thiadiazoles, 1,2,4-triazoles and 1,3-thiazoles by conventional and non-conventional methods was written by Akolkar, H. N.;Karale, B. K.;Randhavane, P. V.;Dalavi, N. R.. And the article was included in Indian Journal of Chemistry in 2017.Recommanded Product: 2,4-Dichlorophenylisothiocyanate This article mentions the following:

A series of novel fluorinated thiazolyl thiosemicarbazides I (R¹ = R² = H, R³ = F; R¹ = R³ = H, R² = Me; R¹ = R³ = Cl, R² = H, etc.), 1,3,4-thiadiazoles II and 1,2,4-triazoles III have been synthesized by using conventional and non-conventional methods. The compounds 1,3-thiazoles IV have been synthesized from thiosemicarbazide I by using conventional method. The structures of synthesized compounds have been confirmed with the help of spectral techniques. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Recommanded Product: 2,4-Dichlorophenylisothiocyanate).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 2,4-Dichlorophenylisothiocyanate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Library Synthesis Using 5,6,7,8-Tetrahydro-1,6-naphthyridines as Scaffolds was written by Zhou, Ya;Beeler, Aaron B.;Cho, Sanghyun;Wang, Yuehong;Franzblau, Scott G.;Snyder, John K.. And the article was included in Journal of Combinatorial Chemistry in 2008.Category: chlorides-buliding-blocks This article mentions the following:

The chem. of 5,6,7,8-tetrahydro-1,6-naphthyridine scaffolds I [R = H, R¹ = Me, R² = Ph, CH₂OPh, n-Bu; R¹ = Ph, R² = 2-Me-4-MeOC₆H₃], synthesized by intramol. cobalt-catalyzed [2 + 2 + 2] cyclizations, has been exploited for library synthesis. Urea, amide, and sulfonamide formations were used in the synthesis of a 101-membered library. Screening of the library for antituberculosis activity revealed three lead compds I [R = (R)-PhCH(Me)NHCO, 4-MeOC₆H₄NHCO, 4-NCC₆H₄SO₂, R¹ = Ph, R² = 2-Me-4-MeOC₆H₃]. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Category: chlorides-buliding-blocks).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: Highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1” binding site was written by Nara, Hiroshi;Sato, Kenjiro;Naito, Takako;Mototani, Hideyuki;Oki, Hideyuki;Yamamoto, Yoshio;Kuno, Haruhiko;Santou, Takashi;Kanzaki, Naoyuki;Terauchi, Jun;Uchikawa, Osamu;Kori, Masakuni. And the article was included in Bioorganic & Medicinal Chemistry in 2014.Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

On the basis of X-ray co-crystal structures of matrix metalloproteinase-13 (MMP-13) in complex with its inhibitors, our structure-based drug design (SBDD) strategy was directed to achieving high affinity through optimal protein-ligand interaction with the unique S1” hydrophobic specificity pocket. This report details the optimization of lead compound 44 to highly potent and selective MMP-13 inhibitors based on fused pyrimidine scaffolds represented by the thienopyrimidin-4-one 26c. Furthermore, we have examined the release of collagen fragments from bovine nasal cartilage in response to a combination of IL-1 and oncostatin M. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Visible-Light Responsive Sucrose-Containing Macrocyclic Host for Cations was written by Sokolowska, Patrycja;Dabrowa, Kajetan;Jarosz, Slawomir. And the article was included in Organic Letters in 2021.Safety of (Chloromethanetriyl)tribenzene This article mentions the following:

Chiral photoresponsive host 1 was prepared by a high-yield Cs₂CO₃-templated macrocyclization. Trans-1 transforms into long-lived cis-1 (25 days) upon irradiation with green light, and the backward transformation is triggered by blue light. Both isomers prefer potassium among alkali metal cations, and cis-1 binds cations stronger than trans-1 (K_cis/K_trans â‰?4.1). ¹H NMR titration experiments as well as d. functional theory studies reveal that sucrose ring oxygen residues and azobenzene nitrogen atoms in 1 contribute to cation coordination. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Safety of (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological screening of some new 5,7-dihydro-4H-thieno[2,3-c]pyran-3-yl containing 1,2,4-triazoles, 1,3,4-oxadiazoles, and 1,3-thiazoles was written by Jadhav, Ranjana K.;Akolkar, Hemant N.;Nikumbh, Arun B.;Karale, Bhausaheb K.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2021.Computed Properties of C7H3Cl2NS This article mentions the following:

Some new 5,7-dihydro-4H-thieno[2,3-c]pyran thiosemicarbazides I [R¹ = H, Cl, OMe, OCF₃, Me, Et, R³ = Cl, H, F] were synthesized from 5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbohydrazide and aryl isothiocyanates in ethanol. Compounds I, on refluxing with 1N NaOH, gave (thieno[2,3-c]pyranyl)(phenyl)-4H-1,2,4-triazole-3-thiols II, and with 4N NaOH in the presence of I₂/KI gave (thieno[2,3-c]pyranyl)-N-phenyl-1,3,4-oxadiazol-2-amines III. When I were reacted with 2-bromo-1-(4-fluorophenyl)ethanone to obtain (11Z)-(thiazol-2(3H)-ylidene)-4H-thieno[2,3-c]pyran-3-carbohydrazides IV. The structures of the synthesized compounds were confirmed by using spectral techniques. The compounds were also screened for their antifungal and antibacterial activity. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Computed Properties of C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Computed Properties of C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Development of androgen-antagonistic coumarinamides with a unique aromatic folded pharmacophore was written by Koga, Hitomi;Negishi, Mai;Kinoshita, Marie;Fujii, Shinya;Mori, Shuichi;Ishigami-Yuasa, Mari;Kawachi, Emiko;Kagechika, Hiroyuki;Tanatani, Aya. And the article was included in International Journal of Molecular Sciences in 2020.Synthetic Route of C8H4ClNO This article mentions the following:

First-generation nonsteroidal androgen receptor (AR) antagonists, such as flutamide (2a) and bicalutamide (3), are effective for most prostate cancer patients, but resistance often appears after several years due to the mutation of AR. Second-generation AR antagonists are effective against some of these castration-resistant prostate cancers, but their structural variety is still limited. In this study, we designed and synthesized 4-methyl-7-(N-alkyl-arylcarboxamido)coumarins as AR antagonist candidates and evaluated their growth-inhibitory activity toward androgen-dependent SC-3 cells. Coumarinamides with a secondary amide bond did not show inhibitory activity, but their N-methylated derivatives exhibited AR-antagonistic activity. Especially, 19b and 31b were more potent than the lead compound 7b, which was comparable to hydroxyflutamide (2b). Conformational anal. showed that the inactive coumarinamides with a secondary amide bond have an extended structure with a trans-amide bond, while the active N-methylated coumarinamides have a folded structure with a cis-amide bond, in which the two aromatic rings are placed face-to-face. Docking study suggested that this folded structure is important for binding to AR. Selected coumarinamide derivatives showed AR-antagonistic activity toward LNCaP cells with T877A AR, and they had weak progesterone receptor (PR)-antagonistic activity. The folded coumarinamide structure appears to be a unique pharmacophore, different from those of conventional AR antagonists. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Synthetic Route of C8H4ClNO).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C8H4ClNO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections was written by Xu, Hang;Yan, Zhong-zuo;Guo, Meng-bi;An, Ran;Wang, Xin;Zhang, Rui;Mou, Yan-hua;Hou, Zhuang;Guo, Chun. And the article was included in European Journal of Medicinal Chemistry in 2021.COA of Formula: C8H9Cl This article mentions the following:

A series of selenium-containing miconazoles. compounds I, II [R = H, 3-F, 2-Me, etc. ; X= F, Cl], III [R = H, 3-F, 2-Me, etc.; X= F, C] were identified as potent antifungal drugs in our previous study. Representative compound I (MIC = 0.01μg/mL against C.alb. 5314) proved efficacious in inhibiting the growth of fungal pathogens. However, further study showed lead compound I exhibited potential hemolysis, significant cytotoxic effect and unfavorable metabolic stability and was therefore modified to overcome these drawbacks. In this article, the further optimization of selenium-containing miconazole derivatives resulted in the discovery of similarly potent compound II [R = 4-F ; X= F] (MIC = 0.02μg/mL against C.alb. 5314), exhibiting a superior pharmacol. profile with decreased rate of metabolism, cytotoxic effect and hemolysis. Furthermore, compound II [R = 4-F ; X= F] showed fungicidal activity against Candida albicans and significant effects on the treatment of resistant Candida albicans infections. Meanwhile, compound II [R = 4-F ; X= F] not only could reduce the ergosterol biosynthesis pathway by inhibiting CYP51, but also inhibited biofilm formation. More importantly, compound II [R = 4-F ; X= F] also shows promising in vivo efficacy after i.p. injection and the PK study of compound II [R = 4-F ; X= F] was evaluated. In addition, mol. docking studies provide a model for the interaction between the compound II [R = 4-F ; X= F] and the CYP51 protein. Overall, it was believed that these selenium-containing miconazole compounds can be further developed for the potential treatment of fungal infections. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9COA of Formula: C8H9Cl).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C8H9Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Benzothiazepine CGP37157 Analogues Exert Cytoprotection in Various in Vitro Models of Neurodegeneration was written by Martinez-Sanz, Francisco J.;Lajarin-Cuesta, Rocio;Moreno-Ortega, Ana J.;Gonzalez-Lafuente, Laura;Fernandez-Morales, Jose C.;Lopez-Arribas, Raquel;Cano-Abad, Maria F.;Rios, Cristobal de los. And the article was included in ACS Chemical Neuroscience in 2015.COA of Formula: C11H14ClNO2 This article mentions the following:

Mitochondria regulate cellular Ca²⁺ oscillations, taking up Ca²⁺ through its uniporter and releasing it through the mitochondrial sodium/calcium exchanger. The role of mitochondria in the regulation of Ca²⁺ cycle has received much attention recently, as it is a central stage in neuronal survival and death processes. Over the last decades, the 4,1-benzothiazepine CGP37157 has been the only available blocker of the mitochondrial sodium/calcium exchanger, although it targets several other calcium transporters. We report the synthesis of 4,1-benzothiazepine derivatives with the goal of enhancing mitochondrial sodium/calcium exchanger blockade and selectivity, and the evaluation of their cytoprotective effect. The compound 4c presented an interesting neuroprotective profile in addition to an important blockade of the mitochondrial sodium/calcium exchanger. The use of this benzothiazepine could help to understand the physiol. functions of the mitochondrial sodium/calcium exchanger. In addition, we hypothesize that a moderate blockade of the mitochondrial sodium/calcium exchanger would provide enhanced neuroprotection in neurons. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6COA of Formula: C11H14ClNO2).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C11H14ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A convenient synthesis of γ,δ-unsaturated N-formyl enamines by Wittig alkenylation of γ,δ-unsaturated diformamides was written by Van Vliet, Michiel C. A.;Meuzelaar, Gerrit J.;Bras, Jerome;Maat, Leendert;Sheldon, Roger A.. And the article was included in Liebigs Annalen/Recueil in 1997.Electric Literature of C25H21Cl2P This article mentions the following:

γ,δ-Unsaturated N-formyl enamines were prepared in 2 steps from readily available γ,δ-unsaturated alcs. The alcs. were converted into the γ,δ-unsaturated diformamides by tosylation, followed by reaction with NaN(CHO)₂. The γ,δ-unsaturated diformamides were applied in a Wittig reaction under mild conditions to give the title compounds with a conjugated enamide group in moderate to high yields. In the experiment, the researchers used many compounds, for example, (2-Chlorobenzyl)triphenylphosphonium chloride (cas: 18583-55-6Electric Literature of C25H21Cl2P).

(2-Chlorobenzyl)triphenylphosphonium chloride (cas: 18583-55-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Electric Literature of C25H21Cl2P

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics