Antibacterial alkylguanidino ureas: Molecular simplification approach, searching for membrane-based MoA was written by D′Agostino, Ilaria;Ardino, Claudia;Poli, Giulio;Sannio, Filomena;Lucidi, Massimiliano;Poggialini, Federica;Visaggio, Daniela;Rango, Enrico;Filippi, Silvia;Petricci, Elena;Visca, Paolo;Botta, Lorenzo;Docquier, Jean-Denis;Dreassi, Elena. And the article was included in European Journal of Medicinal Chemistry in 2022.Synthetic Route of C19H15Cl This article mentions the following:
The ever-faster rise of antimicrobial resistance (AMR) represents a major global Public Health challenge. New chem. entities with innovative Modes of Action (MoAs) are thus desirable. We recently reported the development of a novel class of broad-spectrum bactericidal agents, the AlkylGuanidino Ureas (AGU). Due to their polycationic structure, they likely target bacterial membranes. In order to better understand their MoA, we synthesized a library of AGU derivatives by structural simplification of selected hit compounds and developed specific assays based on membrane models by means of both anal. and computational techniques. Cell-based assays provided exptl. evidence that AGUs disrupt bacterial membranes without showing hemolytic behavior. Hence, we herein report a thorough chem. and biol. characterization of a new series of AGUs obtained through mol. simplification, allowing the rational design of potent antibacterial compounds active on antibiotic-resistant strains. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Synthetic Route of C19H15Cl).
(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Synthetic Route of C19H15Cl
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics