A facile approach to the synthesis of 3,4-disubstituted-2-aminothiazolium derivatives through the use of a “volatilizable” support was written by Li, Yangmei;Giulianotti, Marc;Houghten, Richard A.. And the article was included in Tetrahedron Letters in 2010.Reference of 6590-96-1 This article mentions the following:
A facile solid-phase synthetic approach to the synthesis of amino acid-derived 3,4-disubstituted 2-aminothiazolium derivatives starting from Boc- and Fmoc-protected amino acids was reported. Functionalized aminomethylphenyl silica gel was used as a volatilizable support. The products were cleaved with 10% HF and were obtained in high yields and purities. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Reference of 6590-96-1).
2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Reference of 6590-96-1
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics