Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488 was written by Smith, Victoria C.;Cleghorn, Laura A. T.;Woodland, Andrew;Spinks, Daniel;Hallyburton, Irene;Collie, Iain T.;Mok, N. Yi;Norval, Suzanne;Brenk, Ruth;Fairlamb, Alan H.;Frearson, Julie A.;Read, Kevin D.;Gilbert, Ian H.;Wyatt, Paul G.. And the article was included in ChemMedChem in 2011.Formula: C9H9ClO2 This article mentions the following:
Screening of the Sigma-Aldrich Library of Pharmacol. Active Compounds (LOPAC) against cultured Trypanosoma brucei, the causative agent of African sleeping sickness, resulted in the identification of a number of compounds with selective antiproliferative activity over mammalian cells. These included (+)-(1R,2R)-U50488 (I), a weak opioid agonist with an EC50 value of 59 nM as determined in a T. brucei in vitro assay reported previously. This paper describes the modification of key structural elements of U50488 to investigate structure-activity relationships (SAR) and to optimize the antiproliferative activity and pharmacokinetic properties of this compound In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Formula: C9H9ClO2).
2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Formula: C9H9ClO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics