Steric effects in effector-receptor interactions. Steric difference method and applications was written by Valceanu, Radu;Motoc, Ioan. And the article was included in Revue Roumaine de Chimie in 1982.Category: chlorides-buliding-blocks This article mentions the following:
An improved version of the steric difference method (SD* method) for quant. evaluation of effector-receptor-interactions is given. The method considers both the topol. of the effector and the receptor cavity. The SD* method has the following advantages: (1) the 2 steric parameters involved (SDc* for occupancy of the receptor cavity, SDw* for occupancy of the receptor walls) are easily calculated; (2) these parameters can be used for both structurally related series of compounds (i.e., congeners) and structurally different compounds (i.e., noncongeners); and (3) the method can be applied to a small series of compounds This method may be used for predicting activities of biol. active compounds, i.e., structure-activity prediction. It is illustrated with of anal. of hapten-antibody interactions, where good results were obtained. Three sep. systems were analyzed: (1) benzoate derivative hapten interaction with antibody to p-(p‘-azophenylazo)benzoate derivatives, (2) carboxylate-containing compound hapten interaction with antibody to p-azobenzoate derivatives and (3) benzene arsonate derivative hapten interaction with antibody to p-(p‘-azophenylazo)benzenearsonate derivatives The effects of various substituents on the hapten are shown, as well as the importance of electrostatic interactions. In the experiment, the researchers used many compounds, for example, 3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7Category: chlorides-buliding-blocks).
3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics