Synthesis and biological activities of artemisinin-piperazine-dithiocarbamate derivatives was written by Yu, Jia-Ying;Li, Xue-Qiang;Wei, Meng-Xue. And the article was included in European Journal of Medicinal Chemistry in 2019.Recommanded Product: 1-Chlorooctadecane This article mentions the following:
Twelve derivatives of artemisinin-piperazine-dithiocarbamate, I (R = CH2Ph, CH2C6H4Me-4, n-pentyl, CH2CO2CH2Ph, etc.), have been synthesized, and some of them show good in vitro cytotoxic activity. Compound I (R = CH2C6H4CN-4) (II) exhibits the best inhibitory activity against SMMC-7721 cell lines with an IC50 of 0.0025 ± 0.04 μM for 72 h, but the toxicity was lower against LO2 cell lines with an IC50 of 0.18 ± 0.04 μM for 72 h. The results indicate that compound II is more cytotoxic towards cancer cell lines than towards benign cell lines compared with vincristine in vitro. And compound II also has good inhibitory activity against colon, breast and prostate cancer cells. Meanwhile, we have also proposed the six-member ring mechanism of DMSO in catalyzing the esterification of hydroxyl and acyl chloride. Instead of using the hydroxyl, we can obtain the nucleophilic substitution production simply and efficiently without a Lewis acid, which has not been reported previously. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Recommanded Product: 1-Chlorooctadecane).
1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 1-Chlorooctadecane
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics