Double C-S bond formation via multiple Csp3-H bond cleavage: synthesis of 4-hydroxythiazoles from amides and elemental sulfur under metal-free conditions was written by Chen, Liang;Xuchen, Xinyu;Wang, Fei;Yang, Yuan;Deng, Guobo;Liu, Yilin;Liang, Yun. And the article was included in Organic & Biomolecular Chemistry in 2021.Application of 6834-42-0 This article mentions the following:
A novel and efficient approach for the synthesis of 4-hydroxythiazoles I (R1 = Ph, 1H-indol-3-yl, 1-naphthyl, etc.; R2 = Ph, furan-2-yl, benzo[b]thiophen-2-yl, etc.) from amides R1CH2C(O)NHCH2C(O)R2 and elemental sulfur has been developed. In the presence of P2O5, DMSO and HMPA, this metal-free protocol proceeds smoothly and tolerates a spectrum of functional groups. Furthermore, this strategy involves the process of double Csp3-S bond formation through the cleavage of multiple Csp3-H bonds for the first time. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Application of 6834-42-0).
2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application of 6834-42-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics