Pyridonecarboxylic acids as antibacterial agents. VII. Synthesis and antibacterial activities of 1-(p-fluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-substituted pyridino[2,3-c]pyridazine-3-carboxylic acids was written by Mu, Yongqi;Guo, Huiyuan;Zhang, Zhiping. And the article was included in Zhongguo Kangshengsu Zazhi in 1989.Quality Control of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate This article mentions the following:
Title compound, I (R = OH, Cl, NHNH2, NH2, NMe2, NHMe, PhO, 4-FC6HeNH, cyclopropylamino, pyrrolidino, piperidino, morpholino, piperazino, N–methylpiperazino) were prepared from pyridine II (Z = H2) via cyclization of II (Z = 4-FC6H4NHN:). I had a min. inhibitory concentration of â?00 μg/mL against E. coli 1515. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Quality Control of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate).
Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Quality Control of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics