Chemometrical analysis of substituent effects. IV. Additivity of substituent effects in dissociation of 3,5-disubstituted benzoic acids in organic solvents was written by Pytela, Oldrich;Kulhanek, Jiri;Ludwig, Miroslav. And the article was included in Collection of Czechoslovak Chemical Communications in 1994.Recommanded Product: 56961-33-2 This article mentions the following:
Ten 3,5-disubstituted benzoic acids have been synthesized containing all possible combinations of the following substituents: CH3O, CH3, Cl/Br, NO2. The dissociation constants of these acids have been measured in seven organic solvents (methanol, acetone, DMSO, DMF, acetonitrile, pyridine, 1,2-dichloroethane). It has been found that the effect of disubstitution is smaller than that due to interaction of substituents or their solvation and represents only about 0.2% of the effect caused by the individual substituents. The additivity in 3,5-disubstitution is about 2-3 times as good as that in 3,4-disubstitution. The quant. description of substituent effects at the 3 and 5 positions is additive within the range of validity of the Hammett equation irresp. of the type of the substituent constants adopted, the addition of the multiplicative term being statistically insignificant. The solvent effect on 3,4- and 3,5-disubstituted derivatives is somewhat different at the same value of the reaction constant, due predominantly to the specific solvation of the 4-CH3O and 4-NO2 groups. In the experiment, the researchers used many compounds, for example, 3-Chloro-5-methylbenzoic acid (cas: 56961-33-2Recommanded Product: 56961-33-2).
3-Chloro-5-methylbenzoic acid (cas: 56961-33-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 56961-33-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics