Photoredox catalysed reductive aminomethylation of quaternary benzophenanthridine alkaloids was written by Wang, Xinhao;Wang, Lin;Zhang, Jingxuan;Liu, Yisong;Xie, Hongqi;Zeng, Jianguo;Cheng, Pi. And the article was included in Natural Product Research.Electric Literature of C8H10ClN This article mentions the following:
Reduction of C = N double bond is the most important phase I metabolism process of quaternary benzophenanthridine alkaloids (QBAs). Herein, inspired by the NADPH mediated reduction in QBAs, a visible-light promoted reductive aminomethylation of QBAs for synthesis of 6-substituted benzophenanthridines using QBAs and N,N-dimethylaniline as coupling partners is reported. An α-amino radical that derived from QBAs is supposed to be the key intermediate in this visible-light promoted reductive aminomethylation reaction. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Electric Literature of C8H10ClN).
2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Electric Literature of C8H10ClN
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics