Cu-Catalyzed intermolecular [3 + 3] annulation involving oxidative activation of an unreactive C(sp3)-H bond: access to pyrimidine derivatives from amidines and ketones was written by Guo, Wei;Liu, Dongqing;Liao, Jianhua;Ji, Fanghua;Wu, Wanqing;Jiang, Huanfeng. And the article was included in Organic Chemistry Frontiers in 2017.HPLC of Formula: 18637-02-0 This article mentions the following:
A facile and efficient approach for the synthesis of various pyrimidine derivatives, e.g., I from amidines RC(NH2)=NH (R = Me, Ph, 4-pyridyl, cyclopropyl, etc.) and ketones, e.g., 4-CH3OC6H4C(O)CH2CH3 via a Cu-catalyzed intermol. oxidative coupling process using TEMPO/O2 as a co-oxidant has been developed. This novel protocol features unreactive C(sp3)-H bond amination, a wide range of substrates, good functional group tolerance and mild reaction conditions. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0HPLC of Formula: 18637-02-0).
2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.HPLC of Formula: 18637-02-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics