Cu(OTf)2 catalyzed three component strategy for the synthesis of thienopyridine containing spirooxindoles and their cytotoxic evaluation was written by Parthasarathy, K.;Praveen, C.;Kumar, P. Senthil;Balachandran, C.;Perumal, P. T.. And the article was included in RSC Advances in 2015.Name: 2-(Chloromethyl)-1,3-difluorobenzene This article mentions the following:
Synthesis of novel spirooxindoles e.g., I [R1 = R2 = H; Z = C(O)OCH3; R = 2,5-F2C6H3CH2] via a three component reaction of thienopyridines, isatins and malononitriles under copper catalysis was accomplished. This one-pot, room temperature protocol allowed the synthesis of diversely substituted spirooxindoles I in excellent yield. Cytotoxicity towards COLO320 cells revealed that compound I possessing a 2,6-difluorobenzyl group (IC50 of 49.1 μM) was found to be highly potent among the screened compounds In addition, mol. docking of compound I into caspase-3 receptors exhibited the largest binding energy (-10.5 kcal mol-1) compared to other compounds The formation of a DNA ladder for compound I also supports the exptl. results. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Name: 2-(Chloromethyl)-1,3-difluorobenzene).
2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Name: 2-(Chloromethyl)-1,3-difluorobenzene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics