One-pot regio- and chemo-selective synthesis of thiaazatricyclododecane was written by Alizadeh, Abdolali;Bagherinejad, Akram;Bayat, Fahimeh;Zhu, Long-Guan. And the article was included in Tetrahedron in 2016.Formula: C7H3Cl2NS This article mentions the following:
A highly regio- and chemo-selective heteroannulation protocol for the synthesis of unreported polysubstituted thiaazatricyclododecanes I (R1 = H, Br, Cl, OCH3; R2 = H, Cl; R3 = H, Br; R4 = H, Cl, F) has been developed by a sequential four-component reaction of isoquinoline, 2-bromoacetophenones R1C6H4C(O)CH2Br, aryl isothiocyanates 2-R2-3-R3-4-R4-C6H2NCS, and Me 4-chloro-3-oxobutanoate under mild conditions in CH3CN. The method features formation of various C-N, C-S, and C-C bonds, low-cost and readily available substrates, as well as simple one-pot operation, which makes this process highly profitable. This synthesis serves as a nice addition to chem. in which purification via chromatog. and recrystallization can be avoided, and the pure products were obtained simply by washing the crude products with hexane-Et acetate (10:1). In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Formula: C7H3Cl2NS).
2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Formula: C7H3Cl2NS
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics