Reactions of 3-R-5-nitropyridines with nucleophiles: Nucleophilic substitution vs conjugate addition was written by Bastrakov, Maxim A.;Nikol’skiy, Vladislav V.;Starosotnikov, Alexey M.;Fedyanin, Ivan V.;Shevelev, Svyatoslav A.;Knyazev, Daniil A.. And the article was included in Tetrahedron in 2019.Related Products of 59237-53-5 This article mentions the following:
A number of 3-R-5-nitropyridines I (R1 = H, NO2, Cl, Br, C(O)OMe) were synthesized and their reactions with various types of nucleophiles such as OMe, N3, furan-2-ylmethylsulfanyl, cyclohexylsulfanyl, etc. were investigated. The reaction outcome depends on the nature of a nucleophile, where, in case of anionic O-, N- and S-nucleophiles, the previously unreported substitution of non-activated nitro group occurred while carbon nucleophiles underwent dearomatization of the pyridine ring with the formation of products of 1,2-I (R1 = 4-hydroxy-3,5-dimethylphenyl, 2-cyclopropyl-2-oxoethyl, 3,3-dimethyl-2-oxobutyl, 1H-indol-3-yl, etc.) and 1,4-addition II (R2 = Me, cyclopropyl, t-Bu, Ph, etc.). In the experiment, the researchers used many compounds, for example, Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5Related Products of 59237-53-5).
Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 59237-53-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics