Base-Mediated Generation of Ketenimines from Ynamides: [3+2] Annulation with Azaallyl Anions was written by D’Hollander, Agathe C. A.;Romero, Eugenie;Vijayakumar, Kamsana;Le Houerou, Camille;Retailleau, Pascal;Dodd, Robert H.;Iorga, Bogdan I.;Cariou, Kevin. And the article was included in Advanced Synthesis & Catalysis in 2021.Application of 18437-66-6 This article mentions the following:
Ynamides was underwent a [3+2] cycloaddition with 2-azaallyl anions, obtained from benzylimines under the basic conditions and heat was reported. This reaction between two highly reactive intermediates, both generated in situ from bench stable starting materials, gave access to various nitrogen-rich heterocycles. The reaction usually proceeded with excellent diastereoselectivity, in favor of the cis adduct. Deuteration experiments and DFT calculations helped rationalize the regio- and stereoselectivity of the process as well as the formation of side products. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Application of 18437-66-6).
tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 18437-66-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics