The rate of N-demethylation of N,N-dimethylanilines and N-methylanilines by rat liver microsomes is related to their first ionization potential, their lipophilicity and to a steric bulk factor was written by Galliani, G.;Nali, M.;Rindone, B.;Tollari, S.;Rocchetti, M.;Salmona, M.. And the article was included in Xenobiotica in 1986.Recommanded Product: 2-Chloro-N,N-dimethylaniline This article mentions the following:
The N-demethylation of a series of 12 p-substituted N,N-dimethylanilines [e.g., 4-fluoro-N,N-dimethylaniline (I) [403-46-3]], 9 m-substituted N,N-dimethylanilines, 1 o-substituted N,N-dimethylaniline, and 4 p-substituted N-methylanilines by rat liver microsomes was studied. For each compound, the apparent Vmax and Km values were determined and these parameters were correlated with their electronic, lipophilicity, and steric bulk parameters reported in the literature. Multi-parameter linear regression anal. showed a good correlation between log Vmax and these parameters for the p-substituted N,N-dimethylanilines. A lower degree of correlation was observed with the m-substituted N,N-dimethylanilines. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Recommanded Product: 2-Chloro-N,N-dimethylaniline).
2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 2-Chloro-N,N-dimethylaniline
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics