An efficient silver tetrafluoroborate-catalyzed cycloisomerization of ynamides was written by Ieawsuwan, Winai;Ruchirawat, Somsak. And the article was included in Heterocycles in 2019.Synthetic Route of C11H14ClNO2 This article mentions the following:
A silver catalyzed-cycloisomerization of N-Boc protected ynamides was developed under mild reaction conditions to provide a wide range of oxazolones I [R1 = (CH2)8OTIPS, Ph, 4-FC6H4, etc.; R2 = Ph, 4-ClC6H4, (CH2)2Ph, etc.] in good to excellent yields. Moreover, the acid-promoted Pictet-Spengler cyclization of oxazolones I was described to furnish the corresponding trans-oxazolidones II [R3 = H, OMe; R4 = R5 = OMe] in moderate yields. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Synthetic Route of C11H14ClNO2).
tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Synthetic Route of C11H14ClNO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics