Novel Design of Nonpeptide AVP V2 Receptor Agonists: Structural Requirements for an Agonist Having 1-(4-Aminobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine as a Template was written by Kondo, Kazumi;Ogawa, Hidenori;Shinohara, Tomoichi;Kurimura, Muneaki;Tanada, Yoshihisa;Kan, Keizo;Yamashita, Hiroshi;Nakamura, Shigeki;Hirano, Takahiro;Yamamura, Yoshitaka;Mori, Toyoki;Tominaga, Michiaki;Itai, Akiko. And the article was included in Journal of Medicinal Chemistry in 2000.COA of Formula: C8H6ClFO2 This article mentions the following:
The discovery of a series of nonpeptide arginine vasopressin V2 receptor agonists is described. After identifying the aniline derivative (I) as our lead compound from the metabolites of a previously studied compound that showed antidiuretic activity by po administration to Brattleboro rats, improvements in the in vitro potency involving evaluations of the structural requirements for agonist action and optimizing the structure of the benzoyl moiety have been intensively undertaken. These studies led to a series of compounds e.g. (II) that show potent agonist activity for the V2 receptor. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3COA of Formula: C8H6ClFO2).
Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.COA of Formula: C8H6ClFO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics