Anticancer and immunomodulatory activities of novel 1,8-naphthyridine derivatives was written by Kumar, Vivek;Madaan, Alka;Sanna, Vinod K.;Vishnoi, Manupriya;Joshi, Narendra;Singh, Anu T.;Jaggi, Manu;Sharma, Pramod K.;Irchhaiya, Raghuveer;Burman, Anand C.. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2009.Name: Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate This article mentions the following:
A number of 1,8-naphthyridine derivatives (22-62) have been synthesized and screened for their in vitro cytotoxicity against eight tumors and two non-tumor cell lines. Halogen substituted 1,8-naphthyridine-3-caboxamide derivatives showed potent activity with compound 47 (I) having IC50 of 0.41 and 0.77 μM on MIAPaCa and K-562 cancer cell lines, resp. while, compound 36 had IC50 of 1.19 μM on PA-1 cancer cell line. However, one of the unsubstituted 1,8-naphthyridine-C-3′-heteroaryl derivative 29 showed potent cytotoxicity with IC50 of 0.41 and 1.4 μM on PA-1 and SW620 cancer cell lines, resp. These compounds were also evaluated for anti-inflammatory activity as suggested by downregulation of proinflammatory cytokines. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Name: Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate).
Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Name: Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics