Peptidotriazolamers Inhibit Aβ(1-42) Oligomerization and Cross a Blood-Brain-Barrier Model was written by Tonali, Nicolo;Hericks, Loreen;Schroeder, David C.;Kracker, Oliver;Krzemieniecki, Radoslaw;Kaffy, Julia;Le Joncour, Vadim;Laakkonen, Pirjo;Marion, Antoine;Ongeri, Sandrine;Dodero, Veronica I.;Sewald, Norbert. And the article was included in ChemPlusChem in 2021.Recommanded Product: (Chloromethanetriyl)tribenzene This article mentions the following:
In peptidotriazolamers every second peptide bond is replaced by a 1H-1,2,3-triazole. Such foldamers are expected to bridge the gap in mol. weight between small-mol. drugs and protein-based drugs. Amyloid β (Aβ) aggregates play an important role in Alzheimer′s disease. We studied the impact of amide bond replacements by 1,4-disubstituted 1H-1,2,3-triazoles on the inhibitory activity of the aggregation “hot spots” K16LVFF20 and G39VVIA42 in Aβ(1-42). We found that peptidotriazolamers act as modulators of the Aβ(1-42) oligomerization. Some peptidotriazolamers are able to interfere with the formation of toxic early Aβ oligomers, depending on the position of the triazoles, which is also supported by computational studies. Preliminary in vitro results demonstrate that a highly active peptidotriazolamer is also able to cross the blood-brain-barrier. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Recommanded Product: (Chloromethanetriyl)tribenzene).
(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: (Chloromethanetriyl)tribenzene
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