Benzothiazoles exhibit broad-spectrum antitumor activity: Their potency, structure-activity and structure-metabolism relationships was written by Xie, Xilei;Yan, Yu;Zhu, Ning;Liu, Gang. And the article was included in European Journal of Medicinal Chemistry in 2014.Application of 1711-11-1 This article mentions the following:
An antitumor activity oriented benzothiazole sublibrary was constructed from a hit compound I via a five stepwise procedure. All target compounds were screened for their antitumor activity against 60 human cancer cell lines. Compounds II, III and IV, showing higher potency than hit I, were identified. Particularly, the compound II gave its average 50% growth inhibition (GIC50) at 0.38 μM. Furthermore, incubation in human liver microsome primarily proved their metabolic stability in vitro. General structure-activity and structure-metabolism relationships were both summarized, which provides information on further strategically optimization. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Application of 1711-11-1).
3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application of 1711-11-1
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics