Novel antiprotozoal products: Imidazole and benzimidazole N-oxide derivatives and related compounds was written by Aguirre, Gabriela;Boiani, Mariana;Cerecetto, Hugo;Gerpe, Alejandra;Gonzalez, Mercedes;Sainz, Yolanda Fernandez;Denicola, Ana;De Ocariz, Carmen Ochoa;Nogal, Juan Jose;Montero, David;Escario, Jose Antonio. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2004.Safety of Ethyl 4-chloro-3-nitrobenzoate This article mentions the following:
The syntheses and biol. evaluation of the first anti-protozoa imidazole N-oxide and benzimidazole N-oxide and their derivatives are reported. They were tested in vitro against two different protozoa, Trypanosoma cruzi and Trichomonas vaginalis. Derivative I, ethyl-1-(i-butyloxycarbonyloxy)-6-nitrobenzimidazole-2-carboxylate, displayed activity on both protozoa. Lipophilicity and redox potential were exptl. determined in order to study the relationship with activity of the compounds These properties are well related with the observed bioactivity. Imidazole and benzimidazole N-oxide derivatives are becoming leaders for further chem. modifications and advanced biol. studies. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Safety of Ethyl 4-chloro-3-nitrobenzoate).
Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Safety of Ethyl 4-chloro-3-nitrobenzoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics