3,4,5-Trisubstituted isoxazoles as novel PPARδ agonists was written by Epple, Robert;Russo, Ross;Azimioara, Mihai;Cow, Christopher;Xie, Yongping;Wang, Xing;Wityak, John;Karanewsky, Don;Gerken, Andrea;Iskandar, Maya;Saez, Enrique;Seidel, H. Martin;Tian, Shin-Shay. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Reference of 57017-95-5 This article mentions the following:
The authors report the identification of a novel series of trisubstituted isoxazoles as PPAR activators from a high-throughput screen. A series of structural optimizations led to improved efficacy and excellent functional receptor selectivity for PPARδ. The isoxazoles represent a series of agonists which display a scaffold that lies outside the typical PPAR agonist motif. In the experiment, the researchers used many compounds, for example, Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5Reference of 57017-95-5).
Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Reference of 57017-95-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics