Arylsulfonic acid derivatives. XIV. Synthesis and antibacterial activity of new derivatives of 4-alkoxybenzylsulfonamides was written by Grigoryan, L. A.;Kaldrikyan, M. A.;Engoyan, A. P.;Paronikyan, R. V.. And the article was included in Armyanskii Khimicheskii Zhurnal in 1987.Electric Literature of C10H13ClO3S This article mentions the following:
p-ROC6H4SO2Cl (I; R = C1-C4 n-alkyl, Me2CHCH2) reacted with R1(CH2)nNH2 (R1 = Ph, p-MeOC6H4; n = 1, 2) in aqueous NaOH to give 15 corresponding p-ROC6H4SO2NH(CH2)nR1 (II) in 55-83% yield. II (same R; R1 = Ph, n = 1, 2; R = Me, R1 = p-MeOC6H4, n = 1) reacted with addnl. I (same R) or with p-R2C6H4CH2Cl (R2 = H, MeO) in dry DMF containing LiH to give 14 corresponding (p-ROC6H4SO2)2N(CH2)nR1 (III) in 38-61% yield and 31-33% p-MeOC6H4CH2N(CH2C6H4R2–p)SO2C6H4OEt-p (same R2), resp. III had antibacterial activity, but II did not. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Electric Literature of C10H13ClO3S).
4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Electric Literature of C10H13ClO3S
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics