Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors was written by Guo, Xiaoke;Yang, Qian;Xu, Jing;Zhang, Li;Chu, Hongxi;Yu, Peng;Zhu, Yingying;Wei, Jinglian;Chen, Weilin;Zhang, Yaozhong;Zhang, Xiaojin;Sun, Haopeng;Tang, Yiqun;You, Qidong. And the article was included in Bioorganic & Medicinal Chemistry in 2013.COA of Formula: C10H13ClO3S This article mentions the following:
Atrial fibrillation (AF) is one of the common arrhythmias that threaten human health. Kv1.5 potassium channel is reported as an efficacious and safe target for the treatment of AF. In this paper, we designed and synthesized three series of compounds through modifying the lead compound RH01617 that was screened out by the pharmacophore model we reported earlier. All of the compounds were evaluated by the whole-patch lamp technol. and most of them possessed potent inhibitory activities against Kv1.5. Two of the compounds were evaluated for the target selectivity as well as the pharmacodynamic effects in an isolated rat model. Due to the promising pharmacol. behavior, one compound deserves further pharmacodynamic and pharmacokinetic evaluations. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3COA of Formula: C10H13ClO3S).
4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C10H13ClO3S
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics