Immobilization of copper(II) on mesoporous MCM-41: A highly efficient and recyclable catalyst for tandem oxidative annulation of amidines and methylarenes was written by Jiang, Minhua;Tuo, Yuxin;Cai, Mingzhong. And the article was included in Journal of Porous Materials in 2020.Formula: C7H8Cl2N2 This article mentions the following:
A new 3-(2-aminoethylamino)propyl-functionalized MCM-41-immobilized copper(II) complex [MCM-41-2N-Cu(OAc)2] was easily prepared from com. available and inexpensive 3-(2-aminoethylamino)propyltrimethoxysilane via immobilization on MCM-41, followed by reaction with copper(II) acetate and characterized by various physico-chem. techniques. It was found that this heterogeneous copper complex is a highly efficient catalyst for the tandem oxidative annulation of amidine hydrochlorides RC(=NH)NH2·HCl (R = Me, 4-fluorophenyl, cyclopropyl, 2-pyridinyl, etc.) and methylarenes ArCH3 (Ar = 3,4-dichlorophenyl, 1-naphthyl, 3-thienyl, 4-pyridinyl, etc.) with tert-Bu hydroperoxide as oxidant to give 3,5-disubstituted 1,2,4-oxadiazoles I and can be reused at least eight consecutive trials with almost consistent activity. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Formula: C7H8Cl2N2).
2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Formula: C7H8Cl2N2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics