Synthesis and activity of substituted heteroaromatics as positive allosteric modulators for α4β2α5 nicotinic acetylcholine receptors was written by Jin, Zhuang;Khan, Pasha;Shin, Youseung;Wang, Jingyi;Lin, Li;Cameron, Michael D.;Lindstrom, Jon M.;Kenny, Paul J.;Kamenecka, Theodore M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.COA of Formula: C8H4ClNO This article mentions the following:
The design and synthesis of a series of substituted heteroaromatic α4β2α5 pos. allosteric modulators is reported. The optimization and development of the heteroaromatic series was carried out from NS9283, and several potent analogs, such as 3-(5-(pyridin-3-yl)-2H-tetrazol-2-yl)benzonitrile and 3,3′-(2H-tetrazole-2,5-diyl)dipyridine with good in vitro efficacy were discovered. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1COA of Formula: C8H4ClNO).
3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C8H4ClNO
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics