Synthesis and antitumor activity of novel 6,7,8-trimethoxy N-aryl-substituted-4-aminoquinazoline derivatives was written by Liu, Fang;Huai, Ziyou;Xia, Guotai;Song, Liuping;Li, Sha;Xu, Yulan;Hong, Kangjun;Yao, Mingyue;Liu, Gang;Huang, Yinjiu. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.Category: chlorides-buliding-blocks This article mentions the following:
A series of 6,7,8-trimethoxy-N-aryl-substituted-4-aminoquinazoline derivatives, e.g., I, were synthesized as epidermal growth factor receptor (EGFR) inhibitors, and their antitumor activities were assessed in the gastric cancer cell line SGC7901 using MTT assay. All compounds were found to inhibit SGC7901 cell proliferation, and compound I (IC50 = 0.434 μM) was found to be slightly more effective against SGC7901 cells than epirubicin (IC50 = 5.16 μM). This suggests that compound I can be used as a new substitution structure to develop more efficacious antitumor agents. Western blot anal. showed that treatment with I (40 μM for 30 min) resulted in near complete inhibition of EGF-induced ERK1/2 phosphorylation, indicating that its anti-proliferative effect is largely associated with inhibition of ERK1/2 activation. These data imply that I is a potential anticancer agent capable of inhibiting cell proliferation. In the experiment, the researchers used many compounds, for example, 3-Chloro-2,4-difluoroaniline (cas: 2613-34-5Category: chlorides-buliding-blocks).
3-Chloro-2,4-difluoroaniline (cas: 2613-34-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics