Activator free, expeditious and eco-friendly chlorination of activated arenes by N-chloro-N-(phenylsulfonyl)benzene sulfonamide (NCBSI) was written by Misal, Balu;Palav, Amey;Ganwir, Prerna;Chaturbhuj, Ganesh. And the article was included in Tetrahedron Letters in 2021.Synthetic Route of C7H4ClNO3S This article mentions the following:
N-Chloro-N-(phenylsulfonyl)benzene sulfonamide (NCBSI) was explored for the first time as a chlorinating reagent for direct chlorination of various activated arenes and heterocycles without any activator. A comparative in-silico study was performed to determine the electrophilic character for NCBSI and com. available N-chloro reagents to reveal the reactivity on a theor. viewpoint. The reagent was prepared by an improved method avoiding the use of hazardous t-Bu hypochlorite. This reagent was proved to be very reactive compared to other N-chloro reagents. The precursor of the reagent N-(phenylsulfonyl)benzene sulfonamide was recovered from aqueous spent, which can be recycled to synthesize NCBSI. The eco-friendly protocol was equally applicable for the synthesis of industrially important chloroxylenol as an antibacterial agent. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Synthetic Route of C7H4ClNO3S).
2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Synthetic Route of C7H4ClNO3S
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics