The development of Friedlander heteroannulation through a single electron transfer and energy transfer pathway using methylene blue (MB+) was written by Mohamadpour, Farzaneh. And the article was included in Scientific Reports in 2022.Safety of 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride This article mentions the following:
The radical Friedlander hetero-annulation of 2-aminoaryl ketone and -methylene carbonyl compound was used to develop a green tandem approach for the metal-free synthesis of polysubstitutedquinolines. At room temperature in an ethanol solvent, photo-excited state functions generated from MB+ were used as single-electron transfer (SET) and energy transfer (EnT) catalysts, utilizing visible light as a renewable energy source in the air atm. The purpose of this research is to increase the use of a nonmetal cationic dye that is both inexpensive and widely available. High yields, energy-effectiveness, high atom economy, time-saving features of the reaction, and operational simplicity, and the least amount of a catalyst are the benefits of this study. As a result, a wide range of ecol. and long-term chem. properties are obtained. Polysubstitutedquinolines’ turnover number (TON) and turnover frequency (TOF) have been calculated Surprisingly, such cyclization can be accomplished on a gram scale, indicating that the process has industrial potential. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Safety of 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride).
3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Safety of 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics