Cyclopropanation via the Michael addition was written by Nishiyama, Kazuyoshi;Oda, Junichi;Inouye, Yuzo. And the article was included in Bulletin of the Institute for Chemical Research, Kyoto University in 1974.Application of 7476-66-6 This article mentions the following:
RCH2R1 (R = Ph, R1 = CN) and CH2:C[OP(O)(OMe)2]CO2Me (I) in DMF containing NaH gave cis- and trans-II (R = Ph, R1 = CN) via the RC-R1CH2CH[OP(O)(OMe)2]CO2Me (R = Ph, R1 = CN) intermediate which was formed from the initial Michael adduct, RCHR1CH2C-[OP(O)(OMe)2]CO2Me. The reaction of PhCH2CO2Me with I to give II (R = Ph, R1 = CO2Me) proceeded by the same mechanism. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Application of 7476-66-6).
Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 7476-66-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics