Identification, isolation, synthesis and characterization of isopropyl ester impurity of glibenclamide was written by Pandey, Lawanya Lata;Sarkar, Swagata. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2021.Reference of 3438-16-2 This article mentions the following:
The aim of this work is the detection, identification and elucidation of structure of organic impurity which may present in bulk drugs and pharmaceutical formulations. The control of impurities is currently a critical issue to the healthcare manufacturing Various Regulatory authorities like ICH, USFDA, UK- MHRA and CDSCO are emphasizing on the requirements and the identification of impurities Active Pharmaceutical Ingredients’s (API’s) as well as finished products. International Conference of Harmonisation (ICH) formulated guidelines concerning the control and limit of impurities. In this article we have synthesized iso-Pr impurity of Glibenclamide drug, which is a process related impurity. We have developed a novel method of synthesis of Iso-Pr ester impurity of glibenclamide drug. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Reference of 3438-16-2).
5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Reference of 3438-16-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics