From Sensors to Silencers: Quinoline- and Benzimidazole-Sulfonamides as Inhibitors for Zinc Proteases was written by Rouffet, Matthieu;de Oliveira, Cesar Augusto F.;Udi, Yael;Agrawal, Arpita;Sagi, Irit;McCammon, J. Andrew;Cohen, Seth M.. And the article was included in Journal of the American Chemical Society in 2010.Recommanded Product: 2,4-Dimethoxybenzene-1-sulfonyl chloride This article mentions the following:
Derived from the extensive work in the area of small mol. zinc(II) ion sensors, chelating fragment libraries of quinoline- and benzimidazole-sulfonamides have been prepared and screened against several different zinc(II)-dependent matrix metalloproteinases (MMPs). The fragments show impressive inhibition of these metalloenzymes and preferences for different MMPs based on the nature of the chelating group. The findings show that focused chelator libraries are a powerful strategy for the discovery of lead fragments for metalloprotein inhibition. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Recommanded Product: 2,4-Dimethoxybenzene-1-sulfonyl chloride).
2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 2,4-Dimethoxybenzene-1-sulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics