Assembly of multicyclic isoquinoline scaffolds from pyridines: formal total synthesis of fredericamycin A was written by Wang, Fang-Xin;Yan, Jia-Lei;Liu, Zhixin;Zhu, Tingshun;Liu, Yingguo;Ren, Shi-Chao;Lv, Wen-Xin;Jin, Zhichao;Chi, Yonggui Robin. And the article was included in Chemical Science in 2021.SDS of cas: 442903-28-8 This article mentions the following:
The construction of an isoquinoline skeleton typically starts with benzene derivatives as substrates with the assistance of acids or transition metals. Disclosed here is a concise approach to prepare isoquinoline analogs by starting with pyridines to react with β-ethoxy α,β-unsaturated carbonyl compounds under basic conditions. Multiple substitution patterns and a relatively large number of functional groups (including those sensitive to acidic conditions) can be tolerated the method. In particular, protocol allows for efficient access to tricyclic isoquinolines found in hundreds of natural products with interesting bioactivities. The efficiency and operational simplicity of introducing structural complexity into the isoquinoline frameworks can likely enable the collective synthesis of a large set of natural products. Here show that fredericamycin A could be obtained via a short route by using isoquinoline synthesis as a key step. In the experiment, the researchers used many compounds, for example, Methyl 2,4-dichloronicotinate (cas: 442903-28-8SDS of cas: 442903-28-8).
Methyl 2,4-dichloronicotinate (cas: 442903-28-8) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).SDS of cas: 442903-28-8
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics