Transition-metal-free persulfuration to construct unsymmetrical disulfides and mechanistic study of the sulfur redox process was written by Xiao, Xiao;Feng, Minghao;Jiang, Xuefeng. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2015.Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene This article mentions the following:
A sulfur redox process has been developed between sulfinate and thiosulfate, which efficiently affords diverse unsym. disulfides and provides a new method to modify pharmaceuticals and natural products without requiring an extra oxidant or reductant. A gram-scale investigation further demonstrates the practicality and application potential of this process. Isolated key intermediates and a series of control experiments afford an unusual process, which reveals the mechanism of comproportionation (i.e., redox reaction) and a transition-metal-free sulfur redox process. The synthesis of the target compounds was achieved using sodium thiosulfate pentahydrate (Na2S2O3.5H2O) [i.e., thiosulfuric acid (H2S2O3), sodium salt, hydrate] as a starting material in addition to benzenesulfinic acid sodium salt derivatives, 4-chlorobutanenitrile, 1-chlorbutane, (chloromethyl)benzene derivatives (benzyl chloride). Other starting materials included 4-(trifluoromethyl)benzenesulfonic acid sodium salt, 2-naphthalenesulfinic acid sodium salt (naphthalene derivative), 2,5-dichloro-3-thiophenesulfinc acid sodium salt (thiophene derivative), (1S,4R)-7,7-dimethyl-2-(oxo)bicyclo[2.2.1]heptane-1-methanesulfinic acid sodium salt (camphor derivative), 17-(oxo)estra-1,3,5(10)-triene-3-sulfinic acid sodium salt (estrone derivative, estrogen). In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene).
2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics