Yanik, Hulya et al. published their research in Organic Communications in 2020 | CAS: 6590-96-1

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Computed Properties of C7H3Cl2NS

Synthesis, cytotoxic activities and molecular modeling studies of some 2-aminonaphtho[2,3-d][1,3]thiazole-4,9-dione derivatives was written by Yanik, Hulya;Ayan, Sumeyra;Akdemir, Atilla;Erdogan, Omer;Ustundag, Cem Bulent;Cevik;Yilmaz, Ozge Ozgur. And the article was included in Organic Communications in 2020.Computed Properties of C7H3Cl2NS This article mentions the following:

A series of 2-aminonaphtho[2,3-d][1,3]thiazole-4,9-dione derivatives I (R = 4-methylphenyl, 2,4-dichlorophenyl, cyclohexyl, etc.) was synthesized and their structures were verified with spectral anal. In vitro cytotoxic activities of the synthesized compounds I were evaluated by using MTT assay against MKN-45 (Human Gastric cancer), MDA-MB-231 (Human Breast cancer) and HeLa (Human Cervical cancer) cell lines. Among the synthesized compounds, I (R = 4-trifluoromethylphenyl) inhibited MDA-MB-cell proliferation with an IC50 value of 0.276μM. Compound I (R = 4-fluorophenyl) inhibited HeLa and MKN-45 cell proliferation with IC50 values of 0.336μM and 8.769μM, resp. Compound I (R = 4-methoxyphenyl) inhibited HELA cell proliferation with an IC50 value of 0.269μM. Mol. docking results suggest that the ligands may bind to the hDNA TopoIIβ binding pocket and partially exert their effects. These results propose that 2-aminonaphtho[2,3-d]thiazole-4,9-dion core has important biol. effects and further explorations are worthwhile. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Computed Properties of C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Computed Properties of C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics