Intermolecular Reductive Heck Reaction of Unactivated Aliphatic Alkenes with Organohalides was written by Zheng, Kewang;Xiao, Guanlin;Guo, Tao;Ding, Yalan;Wang, Chengdong;Loh, Teck-Peng;Wu, Xiaojin. And the article was included in Organic Letters in 2020.Application In Synthesis of 5-Bromo-2-chloro-m-xylene This article mentions the following:
A general intermol. reductive Heck reaction of organohalides with both terminal and internal unactivated aliphatic alkenes has been first realized in high yield with complete anti-Markovnikov selectivity. The challenging vinyl bromides, aryl chlorides, and polysubstituted internal alkenes were first applied. More than 100 remote carbofunctionalized alkyl carboxylic acid derivatives were rapidly synthesized from easily accessible starting materials. The synthesis of drug mols. has further demonstrated the wide synthetic utility of this scalable strategy. Preliminary mechanistic studies are consistent with the proposed catalytic cycle. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloro-m-xylene (cas: 206559-40-2Application In Synthesis of 5-Bromo-2-chloro-m-xylene).
5-Bromo-2-chloro-m-xylene (cas: 206559-40-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 5-Bromo-2-chloro-m-xylene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics