Synthesis and evaluation of new thiadiazole derivatives as potential inhibitors of human carbonic anhydrase isozymes (hCA-I and hCA-II) was written by Altintop, Mehlika Dilek;Ozdemir, Ahmet;Kucukoglu, Kaan;Turan-Zitouni, Gulhan;Nadaroglu, Hayrunnisa;Kaplancikli, Zafer Asim. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2015.Application of 6590-96-1 This article mentions the following:
2-[[5-(2,4-Difluoro/dichlorophenylamino)-1,3,4-thiadiazol-2-yl]thio]acetophenone derivatives were designed as human carbonic anhydrase isoenzymes (hCA-I and hCA-II) inhibitor and synthesized. HCA-I and hCA-II were purified from erythrocyte cells by affinity chromatog. The inhibitory effects of 18 newly synthesized acetophenones on hydratase activity of these isoenzymes were studied in vitro. The average IC50 values of the new compounds for hydratase activity ranged from 0.033 to 0.14 渭M for hCA-I and from 0.030 to 0.11 渭M for hCA-II. Among the newly synthesized compounds, 2-[[5-(2,4-dichlorophenylamino)-1,3,4-thiadiazol-2-yl]thio]-4′-bromoacetophenone can be considered as a promising hCA-II inhibitor owing to its selective and potent inhibitory effect on hCA-II. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Application of 6590-96-1).
2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 6590-96-1
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics