Enhancement of Antibiotic Activity by 1,8-Naphthyridine Derivatives against Multi-Resistant Bacterial Strains was written by Araujo-Neto, Jose B. de;Silva, Maria M. C. da;Oliveira-Tintino, Cicera D. de M.;Begnini, Ieda M.;Rebelo, Ricardo A.;Silva, Luiz E. da;Mireski, Sandro L.;Nasato, Michele C.;Krautler, Maria I. L.;Ribeiro-Filho, Jaime;Siyadatpanah, Abolghasem;Wilairatana, Polrat;Coutinho, Henrique D. M.;Tintino, Saulo R.. And the article was included in Molecules in 2021.Category: chlorides-buliding-blocks This article mentions the following:
The purpose of this study was to evaluate the antibacterial and antibiotic-modulating activities of 1,8-naphthyridine derivatives against multi-resistant bacterial strains. The broth microdilution method was used to determine the min. inhibitory concentration (MIC) of the following compounds: 7-acetamido-1,8-naphthyridin-4(1H)-one and 3-trifluoromethyl-N-(5-chloro-1,8-naphthyridin-2-yl)-benzenesulfonamide. The antibiotic-modulating activity was analyzed using subinhibitory concentrations (MIC/8) of these compounds in combination with norfloxacin, ofloxacin, and lomefloxacin. Multi-resistant strains of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were used in both tests. Although the compounds had no direct antibacterial activity (MIC 鈮?1.024渭g/mL), they decreased the MIC of these fluoroquinolones, indicating synergism was obtained from the association of the compounds These results suggested the existence of a structure-activity relationship in this group of compounds with regard to the modulation of antibiotic activity. Therefore, concluded that 1,8-naphthyridine derivatives potentiate the activity of fluoroquinolone antibiotics against multi-resistant bacterial strains, and thereby interesting candidates for the development of drugs against bacterial infections caused by multidrug resistant strains. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Category: chlorides-buliding-blocks).
3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics